产妇妊娠期CA125水平与免疫检验结果及部分生化指标的相关性分析

Correlation analysis of CA125 levels with immunological test results and some biochemical indicators during pregnancy

目的分析产妇妊娠期糖类抗原(CA)125水平与免疫检验结果及部分生化指标的相关性。方法186例妊娠期接受免疫检验的产妇为研究对象,将免疫检验结果为阳性的126例产妇作为观察组,另将60例接受免疫检验的健康产妇作为对照组。分析观察组产妇的免疫检验结果,对比各组产妇妊娠期CA125、肌酐(Cr)、尿素氮(BUN)及血糖(Glu)水平,并分析妊娠期CA125水平与免疫检验指标及部分生化指标的相关性。结果观察组126例产妇中,乙型肝炎(乙肝)表面抗原(HBsAg)阳性(HBsAg阳性组)63例、丙型肝炎(丙肝)抗体(anti-HCV)阳性(anti-HCV阳性组)39例、梅毒抗体(TP抗体)阳性(TP抗体阳性组)24例、人类免疫缺陷病毒抗体(HIV-1/2)抗体阳性0例。HBsAg阳性组、anti-HCV阳性组、TP抗体阳性组的CA125水平分别为(83.14±13.18)、(75.43±8.02)、(69.82±5.17)U/ml,均高于对照组的(14.02±2.06)U/ml,差异有统计学意义(P<0.05)。HBsAg阳性组、anti-HCV阳性组、TP抗体阳性组的Cr、BUN、Glu水平均低于对照组,差异有统计学意义(P<0.05)。妊娠期CA125水平变化与HBsAg阳性、anti-HCV阳性、TP抗体阳性、BUN水平呈正相关(r=0.529、0.458、0.337、0.365,P<0.05)。结论在妊娠期检查中检测CA125水平,并分析其与免疫检验指标及部分生化指标的相关性,能够用于评估艾滋、梅毒、乙肝、丙肝等病的发生风险,便于加强对相关疾病的防治。

Objective To analyze the correlation of carbohydrate antigen(CA)125 levels with immunological test results and some biochemical indicators during pregnancy.Methods A total of 186 women who received immunological tests during pregnancy were studied,and 126 women with positive immunological test results were selected as the observation group,while 60 healthy women who received immunological tests were selected as the control group.The immunological test results of the observation group were analyzed.The levels of CA125,creatinine(Cr),blood urea nitrogen(BUN)and blood glucose(Glu)during pregnancy were compared between the groups,and the correlation between CA125 levels during pregnancy and the immunological test indexes and some biochemical indexes was analyzed.Results Among 126 maternal women in the observation group,63 cases were hepatitis B surface antigen(HBsAg)positive(HBsAg-positive group),39 cases were hepatitis C antibody(anti-HCV)positive(anti-HCV positive group),24 cases were treponema pallidum(TP)antibody positive(TP antibody positive group),and 0 case was human immunodeficiency virus(HIV)-1/2 antibody positive.The CA125 levels in HBsAg positive group,anti-HCV positive group and TP antibody positive group were(83.14±13.18),(75.43±8.02)and(69.82±5.17)U/ml,which were higher than those of(14.02±2.06)U/ml in the control group,and the differences were statistically significant(P<0.05).The levels of Cr,BUN,and Glu in the HBsAg-positive group,anti-HCV-positive group,and TP-antibody-positive group were lower than those in the control group,and the differences were statistically significant(P<0.05).Changes in CA125 levels during pregnancy were positively correlated with HBsAg-positive,anti-HCV-positive,TP-antibody-positive,and BUN levels(r=0.529,0.458,0.337,0.365;P<0.05).Conclusion The detection of CA125 levels during pregnancy and the analysis of its correlation with immunological test indicators and some biochemical indicators can be used to assess the risk of HIV,syphilis,hepatitis B and C,so as to facilitate the prevention and treatment of related diseases.