盐酸羟考酮缓释片治疗中晚期恶性肿瘤疼痛患者的效果

Effects of Oxycodone hydrochloride sustained release tablets in treatment of pain of patients with advanced malignant tumors

目的:观察盐酸羟考酮缓释片治疗中晚期恶性肿瘤疼痛患者的效果。方法:选取2019年1月至2022年1月该院收治的80例中晚期恶性肿瘤患者进行前瞻性研究,采用掷硬币法将其分为对照组和观察组各40例。对照组予以盐酸吗啡缓释片治疗,观察组予以盐酸羟考酮缓释片治疗,比较两组疼痛缓解效果、治疗前后致痛因子[血清5-羟色胺(5-HT)、缓激肽(BK)和脑脊液神经肽-Y(NPY)]水平、睡眠质量[匹兹堡睡眠质量指数量表(PSQI)]评分、生命质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)]评分和不良反应发生情况。结果:观察组疼痛缓解率为95.00%(38/40),高于对照组的77.50%(31/40),差异有统计学意义(P<0.05);治疗后,两组5-HT、BK和NPY水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组PSQI、EORTC QLQ-C30评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为5.00%(2/40),低于对照组的20.00%(8/40),差异有统计学意义(P<0.05)。结论:盐酸羟考酮缓释片治疗中晚期恶性肿瘤疼痛患者可提高疼痛缓解效果,降低致痛因子水平和不良反应发生率,改善睡眠质量和生命质量,效果优于盐酸吗啡缓释片治疗。

Objective:To observe effects of Oxycodone hydrochloride sustained release tablets in treatment of pain of patients with advanced malignant tumors.Methods:A prospective study was conducted on 80 patients with advanced malignant tumors admitted to the hospital from January 2019 to January 2022.They were divided into control group and observation group by using the coin tossing method,40 cases in each.The control group was treated with Morphine hydrochloride sustained-release tablets,while the observation group was treated with Oxycodone hydrochloride sustained-release tablets.The pain relief effect,the levels of pain inducing factors[5-hydroxytryptamine(5-HT),bradykinin(BK),brain neuropeptide-Y(NPY)]before and after the treatment,the sleep quality[Pittsburgh sleep quality index(PSQI)]score,the quality of life[European organization for research and treatment of cancer quality of life(EORTC QLQ-C30)]score,and the adverse reactions were compared between the two groups.Results:The pain relief rate of the observation group was 95.00%(38/40),which was higher than 77.50%(31/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of 5-HT,BK and NPY in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the PSQI and EORTC QLQ-C30 scores of the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the observation group had lower incidence of adverse reactions[5.00%(2/40)]than the control group[20.00%(8/40)],and the difference was statistically significant(P<0.05).Conclusions:Oxycodone hydrochloride sustained-release tablets in the treatment of pain of the patients with advanced malignant tumors can improve the pain relief effects and reduce the levels of pain inducing factors,the sleep quality scores,the quality of life scores and the incidence of adverse reactions.Moreover,it is superior to Morphine hydrochloride sustained-release tablets.