血清C反应蛋白、白细胞介素-6和胃泌素-17水平与腹型过敏性紫癜患儿病情严重程度的相关性

Correlations among serum C-reactive protein,interleukin-6 and gastrin-17 levels and severity of abdominal allergic purpura in children

目的:观察血清C反应蛋白(CRP)、白细胞介素-6(IL-6)和胃泌素-17(G-17)水平与腹型过敏性紫癜(HSP)患儿病情严重程度的相关性。方法:选取2019年1月至2021年1月该院收治的80例腹型HSP患儿,设为观察组,根据病情严重程度不同将其分为轻度组(n=26)、中度组(n=35)和重度组(n=19)。另取同期80名体检健康儿童为对照组,比较两组血清CRP、IL-6和G-17水平,并分析血清CRP、IL-6和G-17水平与腹型HSP患儿病情严重程度的相关性。结果:观察组血清CRP、IL-6水平均高于对照组,血清G-17水平低于对照组,差异有统计学意义(P<0.05);不同病情程度患儿血清CRP、IL-6水平比较,重度组>中度组>轻度组,差异均有统计学意义(P<0.05);不同病情严重程度患儿血清G-17水平比较,重度组<中度组<轻度组,差异均有统计学意义(P<0.05);Pearson相关性分析结果显示,血清CRP、IL-6水平与腹型HSP患儿病情程度呈正相关(r>0,P<0.05),血清G-17水平与腹型HSP患儿病情严重程度呈负相关(r<0,P<0.05)。结论:血清CRP、IL-6水平与腹型HSP患儿病情严重程度呈正相关,血清G-17水平与腹型HSP患儿病情严重程度呈负相关。

Objective:To observe correlations among serum C-reactive protein(CRP),interleukin-6(IL-6)and gastrin-17(G-17)levels and severity of children with abdominal allergic purpura(HSP).Methods:80 children with abdominal HSP admitted to this hospital from January 2019 to January 2021 were selected as the observation group.According to the severity,they were divided into mild children(n=26),moderate children(n=35)and severe children(n=19).Another 80 healthy children were selected as the control group.The levels of serum CRP,IL-6 and G-17 were compared between the two groups.The correlations among the serum CRP,IL-6 and G-17 levels and the severity of abdominal HSP were analyzed.Results:The levels of serum CRP and IL-6 in the observation group were higher than those in the control group,the level of serum G-17 was lower than that in the control group,and the differences were statistically significant(P<0.05).There were significant differences in the CRP and IL-6 levels among the children with different severities(P<0.05),that is:severe group>moderate group>mild group.There was significant difference in the G-17 level among the children with different severities(P<0.05),that is:severe group<moderate group<mild group.Pearson correlation analysis showed that the serum CRP and IL-6 levels were positively correlated with the severity of abdominal HSP,and the serum G-17 level was negatively correlated with the severity of abdominal HSP(P<0.05).Conclusions:The serum CRP and IL-6 levels are positively correlated with the severity of abdominal HSP in the children,and the serum G-17 level is negatively correlated with the severity of abdominal HSP.