骨关节炎:一个持续存在的挑战

Osteoarthritis:an ongoing challenge

骨关节炎(OA)是常见的慢性疾病之一,随着人类预期寿命的延长,其患病率和发病率预计都会上升。OA是一种渐进性的疾病,导致关节功能衰退和生活能力下降,并增加巨大的医疗和社会经济成本。OA的病因是复杂和多因素的,涉及遗传、生物和生物力学。现有的医疗技术还不能使OA患者获得痊愈,关节置换是对终末期OA的一种有效治疗方式,但目前仍面临感染、松动及假体有限的使用寿命等问题。因此,目前研究的重点转向预防和早期OA的治疗,这项任务是具有挑战性的,一些干预措施尽管显示出潜力,减轻了OA的症状甚至延缓病情进展,但仍没有达到理想的程度。临床迫切需要对OA的危险因素、发病机制进行更加深刻地探索,以期未来能够减少OA发病率,提供更多更好的治疗策略。

Osteoarthritis(OA)is one of the most common chronic diseases today,and its prevalence and incidence are expected to increase with the extension of human life expectancy.The disease is progressive,leading to a decline in joint function and living ability,as well as huge medical and socio-economic costs.The etiology of OA is complex and multifactorial,involving genetic,biological and biomechanical factors.Current medical technology does not yet allow patients with OA to be cured.Joint replacement is an effective treatment for end-stage OA,but it still faces problems such as infection,loosening and the limited lifespan of the prosthesis.Therefore,the focus is shifting to prevention and early treatment of OA.This task is challenging,and some interventions,although showing potential to reduce the symptoms of OA or even slow its progression,have fallen short of the ideal.There is an urgent clinical need to explore more deeply the risk factors and pathogenesis of OA in order to reduce the incidence of OA and provide more and better treatment strategies in the future.