ALK、Cx37表达与老年非小细胞肺癌手术患者预后的相关性

Correlation Between the Expression of ALK and Cx37 and the Prognosis of Elderly Patients with Non-small Cell Lung Cancer Surgery

目的 探究ALK、Cx37表达与老年非小细胞肺癌手术患者预后的相关性。方法 选取60例老年NSCLC患者作为研究对象。收集患者临床资料,采用免疫组织化学法检测肿瘤组织ALK、Cx37的表达情况,分析ALK、Cx37水平与其临床病理及患者预后的关系。结果 ALK、Cx37表达水平与患者年龄、性别、吸烟、肿瘤直径以及肿瘤分化程度无关(P>0.05),而与患者TNM分期、有无淋巴结转移相关(P<0.05)。淋巴结转移情况、TNM分期、ALK、Cx37表达情况是影响老年非小细胞肺癌患者预后的相关因素(P<0.05)。多因素logistic回归分析显示,淋巴结转移情况、TNM分期、ALK、Cx37为影响NSCLC患者预后的独立危险因素(P<0.05)。结论 ALK、Cx37表达与老年非小细胞肺癌手术患者预后有关,对老年非小细胞肺癌预后的预测具有重要临床意义。

Objective To explore the correlation between the expression of ALK and Cx37 and the prognosis of elderly patients with non-small cell lung cancer surgery.Methods 60 elderly patients with NSCLC were selected as research objects.Clinical data of patients were collected,and the expression of ALK and Cx37 in tumor tissues was detected by immunohistochemistry to analyze the relationship between ALK and Cx37 levels,clinicopathology and prognosis of patients.Results The expression levels of ALK and Cx37 were not correlated with age,sex,smoking,tumor diameter and degree of tumor differentiation(P>0.05),but were correlated with TNM stage and lymph node metastasis(P<0.05).Lymph node metastasis,TNM stage,ALK and Cx37 expression were related to the prognosis of elderly patients with non-small cell lung cancer(P<0.05).Multivariate logistic regression analysis showed that lymph node metastasis,TNM stage,ALK and Cx37 were independent risk factors for prognosis of NSCLC patients(P<0.05).Conclusion The expressions of ALK and Cx37 are associated with the prognosis of elderly patients undergoing surgery for non-small cell lung cancer,and have important clinical significance for predicting the prognosis of elderly patients with non-small cell lung cancer.