胸腔镜肺癌根治术后切口感染的影响因素分析

Analysis of Factors Influencing Incisional Infection After Thoracoscopic Radical Lung Cancer Surgery

目的 探讨胸腔镜肺癌根治术后切口感染的影响因素。方法 回顾性分析86例行肺癌根治术的患者,根据是否术后出现切口感染分为2组。其中感染组15例,而非感染组71例,比较2组患者的各项指标差异。结果 共86例行胸腔镜肺癌根治术患者中,术后有15例出现切口感染,感染率为17.4%(15/86);感染组患者的手术时间、抗生素应用、糖尿病、降钙素原及C-反应蛋白与未感染组比较有统计学差异(P<0.05),而两组患者的年龄、性别、 TNM分期、病理类型比较无差异(P>0.05);多因素Logistic回归分析结果显示:胸腔镜肺癌根治术切口感染的独立危险因素为手术时间≥3 h、糖尿病、C-反应蛋白及降钙素原,而抗生素应用为胸腔镜肺癌根治术切口感染的保护因素(P<0.05)。结论 手术时间≥3 h、糖尿病、C-反应蛋白及降钙素原均是胸腔镜肺癌根治术切口感染的重要危险因素,而抗生素应用是其保护因素。

Objective To investigate the factors influencing incisional infection after thoracoscopic radical lung cancer surgery.Methods 86 patients who underwent radical lung cancer surgery were retrospectively analyzed and divided into 2 groups according to whether they developed postoperative incisional infection.There were 15 cases in the infected group,while 71 cases in the non-infected group,and the differences in the indexes between the 2 groups were compared.Results 86 patients undergoing radical thoracoscopic lung cancer surgery,15 cases had incisional infection after surgery,with an infection rate of 17.4%(15/86);There was a statistical difference in operation time,antibiotic application,diabetes mellitus,calcitoninogen and C-reactive protein between the infected group and the uninfected group(P<0.05),while there was no difference in age,gender,TNM stage and pathological type between the 2 groups(P>0.05);The results of multi-factor logistic regression analysis showed that the independent risk factors for incisional infection in radical thoracoscopic lung cancer were operative time≥3 h,diabetes,C-reactive protein and calcitoninogen,while antibiotic application was a protective factor for incisional infection in radical thoracoscopic lung cancer(P<0.05).Conclusion Operative time≥3 h,diabetes mellitus,C-reactive protein and calcitoninogen are important risk factors for thoracoscopic radical lung cancer incision infection,and antibiotic application is its protective factor.