晚期肺癌炎症指数与胃癌病理特征的相关性分析

Correlation analysis of inflammatory index of advanced lung cancer and pathological characteristics of gastric cancer

目的 探讨晚期肺癌炎症指数(ALI)与胃癌病理特征的相关性。方法 2018年9月至2020年5月在徐州医科大学附属医院普外科行胃癌根治术的胃癌病人280例作为胃癌组,其中再按ALI水平分为ALI降低组及ALI升高组。以徐州医科大学附属医院体检中心的100名健康人群为对照组,比较胃癌组与对照组ALI、ALI降低组与ALI升高组肿瘤浸润程度、淋巴结转移情况和TNM分期,分析这些指标与ALI之间的相关性。结果 胃癌组ALI水平明显低于对照组[39.17(25.98,59.93)比66.06(51.99,82.98),P<0.05];ALI降低组与ALI升高组比较,肿瘤最大径更大[108(74.5%)例比37(25.5%)例]、浸润更深、淋巴结转移数目更多[128(74.4%)例比44(25.6%)例]、TNM分期更晚(P<0.05);但在肿瘤分化程度上差异无统计学意义(P>0.05)。胃癌组ALI升高预示肿瘤处于I期,浸润深度为T1的可能性大,即胃癌病人ALI升高表明肿瘤处于早期。结论 在胃癌病人中,ALI数值越低,提示肿瘤浸润越深、淋巴结转移越多、肿瘤长径越大及TNM分期越晚,预后越差。

Objective To explore the correlation between the advanced lung cancer inflammation index(ALI)and the pathological features of gastric cancer.Methods Two hundred and eighty patients with gastric cancer who underwent radical gastrectomy in general surgery of the Affiliated Hospital of Xuzhou Medical University from September 2018 to May 2020 were taken as gastric cancer group,and 100 healthy people in physical examination center of the Affiliated Hospital of Xuzhou Medical University were taken as control group.The differences of ALI(ALI=BMI×ALB/NLR)between gastric cancer group and healthy people group,as well as the degree of tumor invasion,lymph node metastasis and TNM stage were compared,and the correlation between these indexes and ALI was analyzed.Results Compared with the control group,the gastric cancer group decreased significantly[39.17(25.98,59.93)vs.66.06(51.99,82.98),P<0.05].Compared with patients with elevated ALI,patients with reduced ALI had larger tumor diameter[108(74.5%)vs.37(25.5%)],deeper invasion,more lymph node metastasis[128(74.4%)vs.44(25.6%)]and later TNM stage(P<0.05).But there was no significant difference in the degree of tumor differentiation(P>0.05).The increase of ALI in gastric cancer group indicated that the tumor was in stage I,and the possibility of invasion depth was high,that is,the increase of ALI in gastric cancer patients indicated that the tumor was in the early stage.Conclusion In patients with gastric cancer,the lower the ALI value,the deeper the tumor invasion,the more lymph node metastasis,the larger the tumor diameter and the later TNM stage,the worse the prognosis.