绝经后子宫内膜癌病人卵巢静脉血清雌二醇、睾酮及癌胚抗原水平与微卫星状态的相关性分析

Correlation analysis of microsatellite status and levels of estradiol,testosterone,CEA in ovarian vein in postmenopausal patients with endometrial carcinoma

目的 探讨绝经后子宫内膜癌(EC)病人血清雌二醇(E2)、睾酮(T)及癌胚抗原(CEA)水平与临床病理特征及微卫星状态的相关性。方法 选取2020年11月至2021年10月徐州医科大学附属连云港医院绝经后子宫内膜癌手术治疗病人62例为观察组,另外选择同期入院的绝经后子宫内膜正常手术治疗病人60例为对照组。检测两组卵巢静脉血中雌二醇、睾酮及CEA水平,分析其与子宫内膜癌临床病理特征的相关性,并探讨其与微卫星状态的关系。结果 观察组绝经年龄更高[(52.35±2.50)岁比(49.92±4.01)岁],体质量指数(BMI)更高[(27.28±4.59)kg/m^(2)比(24.85±2.86)kg/m^(2)],子宫内膜厚度更大[(10.20±5.07)mm比(4.46±2.33)mm],差异有统计学意义(P<0.05);在卵巢静脉血中,观察组雌二醇[(58.03±9.63)ng/L比(31.23±17.66)ng/L]、睾酮[(110.07±29.63)ng/dL比(72.77±41.22)ng/dL]及CEA[(14.38±2.52)μg/L比(4.21±1.81)μg/L]水平高于对照组,差异有统计学意义(P<0.05)。观察组病人卵巢静脉血清睾酮及雌二醇水平与肿瘤FIGO分期、肌层浸润深度呈负相关(P<0.05),观察组病人卵巢静脉血CEA水平与肿瘤FIGO分期、分化程度呈正相关(P<0.05),与肌层浸润深度呈负相关(P<0.05)。观察组中微卫星不稳定(MSI)病人卵巢静脉血睾酮、雌二醇及CEA水平高于微卫星稳定(MSS)病人,差异有统计学意义(P<0.05)。结论绝经后子宫内膜癌病人卵巢静脉血中雌二醇、睾酮及CEA水平明显高于子宫内膜正常病人,且与EC的病理特征相关,睾酮、雌二醇及CEA水平与子宫内膜癌微卫星状态相关。

Objective To investigate the correlation between the levels of estradiol(E2),testosterone(T)and carcinoembryonic antigen(CEA)and clinicopathological characteristics as well as microsatellite status in postmenopausal patients with endometrial carcinoma(EC).Methods Sixty-two patients with postmenopausal EC undergoing surgery in The Affiliated Lianyungang Hospital of Xuzhou Medical University from November 2020 to October 2021 were selected as the study group,and 60 patients with normal postmenopausal endometrium undergoing surgery during the same period were selected as the control group.The levels of E2,T and CEA in ovarian venous blood of the two groups were detected to analyze the relationship between them and the clinicopathological characteristics of EC,and to explore their correlation with microsatellite status of EC.Results Patients in the study group had older age of menopause[(52.35±2.50)years vs.(49.92±4.01)years],higher body mass index(BMI)[(27.28±4.59)kg/m²vs.(24.85±2.86)kg/m²]and thicker endometrial thickness[(10.20±5.07)mm vs.(4.46±2.33)mm],and the differences were statistically significant(P<0.05).The levels of E2[(58.03±9.63)ng/L vs.(31.23±17.66)ng/L],T[(110.07±29.63)ng/dL vs.(72.77±41.22)ng/dL]and CEA[(14.38±2.52)μg/L vs.(4.21±1.81)μg/L]in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum T and E2 in ovarian vein were negatively correlated with tumor FIGO staging and the depth of myometrial invasion in the study group(P<0.05),while the level of CEA in ovarian venous blood was positively correlated with tumor FIGO staging and differentiation degree in the study group(P<0.05),and was negatively correlated with the depth of myometrial invasion(P<0.05).In the study group,the levels of T,E2 and CEA in ovarian venous blood of microsatellite instability(MSI)patients were higher than those of microsatellite stability(MSS)patients,and the differences were statistically significant(P<0.05).Conclusion The levels of E2,T and CEA in ovarian venous blood of postmenopausal patients with endometrial cancer are significantly higher than those of patients with normal endometrium,which are correlated with the pathological features of EC as well as the microsatellite status of endometrial cancer.