460例急性呼吸道感染患儿病原学分析

Etiological analysis of 460 children with acute respiratory tract infection

目的分析急性呼吸道感染(ARI)患儿呼吸道非细菌性病原体的感染特点,为急性呼吸道感染临床预防和诊治提供依据。方法选取2016年1月-2018年3月应急总医院儿科门诊确诊为ARI的患儿纳入研究,采用实时荧光定量聚合酶链反应(PCR)法进行多种病原体检测,明确致病病原体。结果共收集病例460例,检出致病病原体总阳性率为68.0%,未检出肺炎衣原体(CP),流感病毒(IV)阳性检出率最高,为30.2%,其次是副流感病毒(PIV),为16.3%,肺炎支原体(MP)为5.7%,肠道病毒(EV)为5.7%。单病原感染者占70.2%,双病原感染(即双重感染)者占8.9%,3种及以上病原同时检出者占1.3%。结论IV是急性呼吸道感染患儿的主要病原体,早期检测呼吸道病原体,将有助于儿科医生诊治和控制呼吸道感染。

Objective To analyze the characteristics of etiology in children with acute respiratory infection,and to provide evidence for clinical prevention,diagnosis and treatment.Methods Those children diagnosed as ARI in the department of pediatrics,Emergency General Hospital from January 2016 to March 2018 were included in the study.Real-time fluorescence quantitative PCR were used to detect and identify the pathogens.Results A total of 460 cases were collected,with a total positive rate of 68.0%.Chlamydia pneumoniae was not detected.The positive rate of influenza viruses were the highest(30.2%),followed by parainfluenza virus(16.3%),mycoplasma pneumoniae(5.7%)and enterovirus(5.7%).Single pathogen infection,double pathogen infection(i.e.,double infection)and three or more pathogens at the same time(i.e.,multiple infection)accounted for 70.2%,8.9%and 1.3%.Conclusions IV is the main pathogen in children with acute respiratory tract infection.Early detection of respiratory tract pathogens will help pediatricians diagnose,treat and control respiratory tract infections.