肿瘤相关成纤维细胞在结直肠癌中的作用及相关治疗的研究进展

Research progress in the role of cancer-associated fibroblasts in colorectal cancer and related therapies

肿瘤相关成纤维细胞(cancer-associated fibroblasts,CAFs)主要来源于肿瘤微环境中被激活的正常成纤维细胞和间充质干细胞。CAFs能够通过分泌多种小分子生物活性物质调控肿瘤细胞的增殖、侵袭、耐药等生物学行为,并通过细胞间相互作用影响微环境中免疫细胞的活性,进而影响肿瘤患者的预后。近年来,关于CAFs的标志物、活化机制、生物作用以及单细胞测序的研究取得一些进展,靶向CAFs治疗也有望成为结直肠癌(colorectal cancer,CRC)新的治疗策略。本文主要对CAFs的来源、活化与募集以及这一细胞亚群在CRC中的研究进展进行综述,为CAFs在CRC中的研究及临床应用提供新的视角。

Activated fibroblasts in the tumor microenvironment(TME)are considered to be the primary source of cancer-associated fibroblasts(CAFs).In colorectal cancer,CAFs regulate immune cells in the TME and modulate biological behaviors,such as drug resistance,migration,and invasion,by secreting bioactive molecular substances.Therefore,CAFs affect the survival and prognosis of patients with colorectal cancer.Recently,experts in the field have identified many CAF-associated biomarkers and genes.Novel colorectal cancer therapies target CAFs as they are key players in the disease.This paper reviews the source,activation,and recruitment of CAFs and the research progress made regarding this cell population in colorectal cancer,thus providing new perspectives and directions for the research and clinical application of CAFs in colorectal cancer.