腹壁创伤止血急救装置应用效果的动物试验

Animal experiment on application effect of hemostatic emergency device for abdominal wall trauma

目的通过动物试验评估腹壁创伤止血急救装置的有效性及安全性。方法选取日本大耳白兔40只,建立腹壁缺损动物模型,随机分为实验组(使用腹壁创伤止血急救装置)和对照组(常规纱布填塞)各20只,对比分析两组动物的生命体征(心电情况)、存活情况,以及腹壁损伤部位的出血及肠管溢出情况。结果与对照组相比,实验组的早期存活率高(P=0.028),止血效果好(P<0.001),生命体征更平稳(P=0.013),且肠管溢出率更低(P<0.001)。实验组的总体生存率明显高于对照组(P=0.027),止血急救装置的止血总有效率高达85%。结论研制的新型腹壁创伤止血急救装置在动物试验中应用安全有效,可通过临床试验进一步验证其效能。

Objective To evaluate the efficacy and safety of hemostatic emergency device for abdominal wall trauma through animal experiments.Methods Forty Japanese white rabbits with large ears were selected to establish an animal model of abdominal wall defect,and then were randomly divided into experimental group(using hemostatic emergency device for abdominal wall trauma)and control group(conventional gauze packing).Results Compared with the control group,the experimental group had higher early survival rate(P=0.028),better hemostatic effect(P<0.001),more stable vital signs(P=0.013),and lower bowel overflow rate(P<0.001).The overall survival rate of the experimental group was significantly higher than that of the control group(P=0.027),and the total effective rate of the hemostatic emergency device was up to 85%.Conclusion Novel hemostatic emergency device for abdominal wall trauma is safe and effective in animal experiments,and its efficacy can be further verified by clinical trials.