栀子活性成分改善肥胖相关胰岛素抵抗的作用机制研究进展

Research Progress on the Mechanism of Active Ingredients of Zhizi(Gardeniae Fructus)in Improving Obesity Related Insulin Resistance

归纳总结栀子活性成分治疗肥胖相关胰岛素抵抗的作用机制,认为栀子活性成分丰富且安全,药理作用广泛。其中环烯醚萜苷类、藏红花苷类和有机酸酯类主要通过3种途径来改善肥胖相关胰岛素抵抗:阻止胰岛素抵抗相关促炎性细胞因子及脂肪因子释放,对抗氧化应激,减轻机体炎症损伤,纠正肥胖相关代谢紊乱;激活胰岛素信号传导通路,提高胰岛素敏感性,保护胰岛细胞功能,维持体内葡萄糖稳态;抑制异位脂质沉积,逆转腹型肥胖人群胰岛素抵抗,改善糖脂代谢障碍,并降低肥胖患者体质量指数。

The mechanism of the active ingredients of Zhizi(Gardeniae Fructus)in the treatment of obesity related insulin resistance was summarized,and it was believed that the active ingredients of Zhizi(Gardeniae Fructus)were rich and safe,with extensive pharmacological effects.Among them,iridoid glycosides,saffron glycosides and organic esters mainly improve obesity-related insulin resistance through three ways.Firstly,Prevent the release of pro-inflammatory factors and adipose factors related to insulin resistance,combat oxidative stress,reduce the inflammatory damage of the body,and correct obesity-related metabolic disorders.Secondly,activate insulin signal transduction pathway,improve insulin sensitivity,protect islet cell function,and maintain glucose homeostasis in vivo.Thirdly,inhibit ectopic lipid deposition,reverse insulin resistance of abdominal obesity,improve glucose and lipid metabolism disorder,and reduce body mass index of obese patients.