基于“肠道菌群-胆汁酸互作”论腹泻型肠易激综合征“土虚木郁”病机的生物学内涵

The Biological Connotation of"Earth Deficiency and Wood Constraint"in IBS-D Based on"Intestinal Flora-bile Acid Interaction"

肠道菌群与胆汁酸代谢的互作紊乱是腹泻型肠易激综合征(IBS-D)发病的病理基础。结合现代医学及分子生物学研究成果,认为肠道菌群紊乱与胆汁酸代谢异常分别和中医“土虚”“木郁”原理相通,故可以从“土虚木郁”“肠道菌群-胆汁酸互作”两方面为IBS-D的治疗提供理论依据,通过中医健脾和胃、疏肝利胆之法,从而调节“肠道菌群-胆汁酸互作”失衡,最终改善IBS-D症状。

The interaction disorder between intestinal flora and bile acid metabolism is the pathological basis of diarrhea-type irritable bowel syndrome(IBS-D).Combining the research results of modern medicine and molecular biology,it is concluded that intestinal flora disorder and abnormal bile acid metabolism are respectively similar to the principles of"earth deficiency"and"wood constraint"in traditional Chinese medicine.Therefore,theoretical basis can be provided for the treatment of IBS-D from the two aspects of"earth deficiency and wood constraint"and"intestinal flora-bile acid interaction",through traditional Chinese medicine to invigorate spleen and harmonize stomach,soothing liver and promoting bile secretion,so as to adjust the imbalance of"intestinal flora-bile acid interaction",and finally improve IBS-D symptoms.