妊娠早期女性非稳态负荷水平与抑郁的相关性研究

Correlation between Allostatic Load Level and Depression among Women in Early Pregnancy

背景 已知慢性应激与抑郁发生相关,非稳态负荷(AL)作为评估机体慢性应激反应的综合生理指标可能在抑郁的发生过程中起着重要作用。目的 探讨妊娠早期女性AL水平与抑郁的关系。方法 采用便利抽样法,选取2021年11月—2022年6月于中国人民解放军联勤保障部队第901医院、六安市金安区妇幼保健院产检的630例妊娠早期女性为研究对象,根据有无抑郁分为抑郁组(n=162)和非抑郁组(n=468)。采用一般资料调查表、妊娠相关焦虑量表、爱丁堡产后抑郁量表进行问卷调查,通过体格检查和实验室检查收集AL相关数据。采用多因素Logistic回归模型分析妊娠早期女性AL与抑郁的相关性。结果 630例妊娠早期女性抑郁发生率为25.7%(162/630)。低水平AL(AL<3分)孕妇427例(67.8%),高水平AL(AL≥3分)孕妇203例(32.2%)。多因素Logistic回归分析显示,高水平AL是妊娠早期女性抑郁的危险因素[OR=1.651,95%CI(1.096,2.489),P<0.05]。结论 妊娠早期女性AL与抑郁存在正向关联,高水平AL会增加抑郁的发生风险。

Background Chronic stress is known to be associated with the onset of depression,allostatic load(AL)may play a significant role in the pathogenesis of depression as a comprehensive physiological index to evaluate response to the chronic stress.Objective To identify the association between AL level and depression among women in early pregnancy.Methods 630 Women in early pregnancy who underwent prenatal examination in the 901 Hospital,Joint Logistic Support Force of the Chinese People's Liberation Army,Jin'an Maternal and Child Health Care Hospital from November 2021 to June 2022 were selected as the research subjects by using convenience sampling method,and were divided into the depression group(n=162)and non-depression group(n=468)according to presence or absence of depression.The general information questionnaire,Pregnancy-specific Anxiety Questionnaire and Edinburgh Postnatal Depression Scale were used for questionnaire survey,ALrelated data were collected by physical examination and laboratory tests.Multivariate Logistic regression model was used to analyze the association between AL level and depression among women in early pregnancy.Results A total of 630 pregnant women in early pregnancy were enrolled with the depression incidence of 25.7%(162/630),including 427 pregnant women(67.8%)with low AL level(AL<3)and 203(32.2%)with high AL level(AL≥3).Multivariate Logistic regression analysis showed that high AL level was the risk factor for depression among women in early pregnancy〔OR=1.651,95%CI(1.096,2.489),P<0.05〕.Conclusion There is a positive association between AL level and depression among women in early pregnancy,high AL level will increase the risk of depression.