肝内胆管癌患者预后的影响因素分析

Analysis of the Influencing Factors of Surgical Prognosis in Patients with Intrahepatic Cholangiocarcinoma

【目的】探讨肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)患者预后的影响因素。【方法】收集福建医科大学孟超肝胆医院收治的64例ICC患者的临床资料,采用单因素、多因素COX回归模型分析ICC患者预后的影响因素,采用Kaplan-Meier生存曲线分析不同因素对ICC患者预后的影响。【结果】糖链抗原19-9(CA19-9)升高、肝外转移及大胆管型ICC是影响ICC患者预后的独立危险因素;CA19-9升高、肝外转移及大胆管型ICC患者预后较差(均P<0.05)。【结论】CA19-9升高、发生肝外转移以及大胆管型ICC可显著影响ICC患者预后。

【Objective】To investigate the independent risk factors affecting the surgical prognosis of patients with intrahepatic cholangiocarcinoma(ICC).【Methods】The clinicopathological data and prognostic information of 64 ICC patients were collected.Univariate and multivariate COX proportional hazards regression models were used to analyze the independent risk factors affecting the prognosis,and Kaplan-Meier survival curves were drawn to compare the effects of different factors on the prognosis of patients.【Results】Elevated carbohydrate antigen 19-9(CA19-9),extrahepatic metastasis and large duct type of ICC were independent risk factors for the prognosis of patients with ICC.The prognosis of patients with elevated CA19-9,extrahepatic metastasis and large duct ICC was poor,and the differences were statistically significant(all P<0.05).【Conclusion】Elevated CA19-9,extrahepatic metastasis and ICC with large duct type are independent risk factors for the prognosis of patients with ICC.