平均血小板体积与急性脑梗死患者近期预后的相关性分析

Relationship between Mean Platelet Volume and Short-term Clinical Prognosis in Patients with Acute Cerebral Infarction

【目的】探讨平均血小板体积(MPV)与急性脑梗死(ACI)患者30 d内临床预后的相关性。【方法】纳入发病24 h内在本院就诊的ACI患者共50例,经常规有效治疗后,有3例在院内死亡,余47例好转出院,出院后于距发病30 d时行改良Rankin预后等级量表评分(mRS),根据mRS将患者分为预后良好组(mRS≤2分,n=33)以及预后不良组(mRS>2分,n=14)。收集所有受试者入院即刻时循环MPV水平,分析MPV与ACI发生后30 d临床预后的关系。采用受试者工作特征(ROC)曲线评价MPV作为预测ACI患者临床预后标记物的价值,同时应用二元Logistic回归分析MPV是否为预后不良的独立危险因素。【结果】预后不良组入院即刻循环MPV水平为(13.44±1.73)fL,显著高于预后良好组的(11.17±2.00)fL,且差异有统计学意义(P<0.05);MPV作为预测ACI患者30 d内预后不良具有中等诊断效能,其ROC曲线下面积(AUC)(95%CI)为0.83(0.72~0.95),同时二元Logistic回归分析证实MPV是ACI患者30 d内发生预后不良的独立危险因素。【结论】MPV是ACI患者30 d内预后不良的独立危险因素,且是潜在的评估ACI患者预后不良的指标。

【Objective】To analyze the relationship between mean platelet volume(MPV)and clinical prognosis within 30 days of acute cerebral infarction(ACI).【Methods】A total of 50 patients with ACI who were diagnosed within 24 hours in our hospital were enrolled in the study.After conventional effective treatment,3 patients died in the hospital,and the remaining 47 patients were discharged after treatment.The mRS score was performed from 47 patients with 30 days after discharge.According to the mRS scores,patients were divided into the good prognosis group(mRS≤2 score,n=33)and the poor prognosis group(mRS>2 score,n=14).The level of MPV were measured at admission,and the relationship between MPV and clinical prognosis of 30 days after ACI was analyzed.The receiver operating characteristic curve(ROC)was used to evaluate the value of MPV as a predictor of clinical prognosis in patients with ACI and the logistic regression analysis was used to determine whether MPV was an independent risk factor for poor prognosis.【Results】The circulating MPV level of the poor prognosis group was(13.44±1.73)fL immediately after admission,which was significantly higher than(11.17±2.00)fL in the good prognosis group,and the difference was statistically significant(P<0.05).MPV had a moderate diagnostic efficacy for poor prognosis of ACI patients and the area under the ROC curve(AUC)(95%CI)was 0.83(0.72-0.95).Logistic regression analysis showed that MPV was an independent risk factor for poor prognosis within 30 days of ACI patients.【Conclusion】MPV is an independent risk factor for poor prognosis in ACI patients within 30 days,and it is a potential marker for evaluating poor prognosis in ACI patients.