基于医院卫生技术评估体系的4种口服铁剂的综合评价

Comprehensive Assessment on Four Oral Iron Preparations Based on Hospital-based Healthtechnology Assessment System

目的:基于医院卫生技术评估(HB-HTA)体系,对硫酸亚铁片、乳酸亚铁胶囊、多糖铁复合物胶囊和琥珀酸亚铁片等4种口服铁剂的临床价值进行多维度综合评价,为医院药品目录动态调整、临床合理使用口服铁剂类药物等提供循证依据。方法:根据《中国医疗机构药品评价与遴选快速指南》并结合眉山市人民医院实际情况,制订百分制评分体系,从药品药学特性、有效性、安全性、经济性及其他属性共5个方面分别对硫酸亚铁片、乳酸亚铁胶囊、多糖铁复合物胶囊和琥珀酸亚铁片开展评价。结果:4种口服铁剂的评分在40~70分,其中硫酸亚铁片为57.5分,乳酸亚铁胶囊为43.5分,琥珀酸亚铁片为64.5分,多糖铁复合物胶囊为69.0分。结论:基于HB-HTA对4种口服铁剂进行多维度综合评价发现,与其他3种口服铁剂比较,乳酸亚铁胶囊在经济性、医保属性方面差距较大,可为医院遴选与合理使用口服铁剂提供参考。

OBJECTIVE:Based on hospital-based healthtechnology assessment(HB-HTA)system,the multi-dimensional comprehensive assessment on the clinical value of four oral iron preparations were performed,including Ferrous sulfate tablets,Ferrous lactate capsules,Polysaccharide-iron complex capsules and Ferrous succinate tablets,so as to provide evidence-based reference for dynamic regulation of hospital drug catalogue and rational application of oral iron agents.METHODS:According to the Quick Guide for Drug Evaluation and Selection in Chinese Medical Institutions and taking into account the actual situation of Meishan City People’s Hospital,the percentage scoring system was developed to perform assessment on Ferrous sulfate tablets,Ferrous lactate capsules,Polysaccharide-iron complex capsules and Ferrous succinate tablets from the aspects of pharmacological properties,effectiveness,safety,economy and other attributes.RESULTS:The scores of the four oral iron preparations ranged from 40 to 70 points,with the Ferrous sulfate tablets was 57.5 points,the Ferrous lactate capsules was 43.5 points,the Ferrous succinate tablets was 64.5 points and the Polysaccharide-iron complex capsules was 69.0 points.CONCLUSIONS:The multi-dimensional comprehensive assessment on the four oral iron preparations based on HB-HTA indicates that Ferrous lactate capsules has a greater gap in terms of economic and medical insurance attributes compared with the other three oral iron preparations,which can provide reference for the selection and rational application of oral iron preparations.