血清S-ChE、NLR联合LDH对细菌性血流感染脓毒症患者预后的预测分析

Predictive analysis of serum S⁃ChE,NLR combined with LDH on the prognosis of sepsis patients with bacterial bloodstream infection

目的探讨血清胆碱酯酶(S-ChE)、中性粒细胞淋巴细胞比值(NLR)联合乳酸脱氢酶(LDH)对细菌性血流感染脓毒症患者预后的预测价值。方法选取2020年1月至2022年6月河北北方学院附属第一医院就诊的84例细菌性血流感染脓毒症患者作为研究对象。依据患者入院后90 d内的生存情况分为死亡组(n=29)和存活组(n=55),比较两组一般资料和相关实验室指标,Logistic回归分析影响细菌性血流感染脓毒症患者预后的危险因素以及ROC曲线,分析血清S-ChE、NLR联合LDH对细菌性血流感染脓毒症患者预后不良的预测价值。结果两组住院时间、合并休克、APACHEⅡ评分、血清S-ChE、NLR、LDH水平比较,差异均有统计学意义(t/χ^(2)=2.720、5.836、4.870、13.292、3.869、5.371,P均<0.05);Logistic回归分析结果显示,低S-ChE、高NLR以及高LDH为细菌性血流感染脓毒症患者预后结局的独立影响因素(P<0.05);ROC曲线分析结果显示,S-ChE、NLR和LDH联合检测对细菌性血流感染脓毒症患者预后预测的AUC=0.996(95%CI:0.989~1.000)。结论血清S-ChE、NLR和LDH联合检测在细菌性血流感染脓毒症患者预后评估方面具有较高的价值。

Objective To investigate the predictive value of serum cholinesterase(S⁃ChE),neutrophil lymphocyte ratio(NLR)combined with lactate dehydrogenase(LDH)on the prognosis of sepsis patients with bacterial bloodstream infection.Methods A total of 84 sepsis patients with bacterial bloodstream infection who were treated in the First Affiliated Hospital of Hebei North University from January 2020 to June 2022 were selected as subjects.The patients were divided into the death group(n=29)and the survival group(n=55)according to the survival condition within 90 days after admission.The general data and related laboratory indicators were compared between the two groups.Logistic regression analysis was used to analyze the risk factors affecting the prognosis of sepsis patients with bacterial bloodstream infection and ROC curve was used to analyze the predictive value of serum S⁃ChE,NLR combined with LDH on the poor prognosis of sepsis patients with bacterial bloodstream infection.Results Univariate analysis showed that there were significant differences in hospitalization time,combined shock,APACHE II score,serum S⁃ChE,NLR and LDH levels between the two groups(t/χ^(2)=2.720,5.836,4.870,13.292,3.869,5.371,P<0.05).The results of Logsitic regression analysis showed that low S⁃ChE,high NLR and high LDH were independent influencing factors for the prognosis of sepsis patients with bacterial bloodstream infection(P<0.05).The ROC curve analysis results showed that the AUC of the prognosis prediction of patients with bacterial blood flow infection sepsis by the combined detection of S⁃ChE,NLR and LDH was 0.996(95%CI:0.989~1.000).Conclusion The combined detection of serum S⁃ChE,NLR and LDH has a high value in evaluating the prognosis of sepsis patients with bacterial bloodstream infection.