阿托伐他汀联合阿司匹林治疗缺血性脑卒中的效果观察

Observation on the effect of atorvastatin combined with aspirin in the treatment of ischemic stroke

目的分析缺血性脑卒中患者采取阿托伐他汀联合阿司匹林治疗的效果。方法62例缺血性脑卒中患者,采取抽签法分为观察组和对照组,每组31例。对照组应用阿司匹林治疗,观察组在对照组的基础上加用阿托伐他汀治疗。比较两组治疗效果、不良反应(头晕、呕吐、神志不清、肠胃不适等)发生情况以及治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数、血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平。结果观察组治疗总有效率93.55%高于对照组的70.97%,差异具有统计学意义(P<0.05)。治疗后,观察组患者NIHSS评分(7.66±1.24)分低于对照组的(14.40±2.55)分,Barthel指数(82.01±3.10)分高于对照组的(57.54±2.60)分,差异均具有统计学意义(P<0.05)。治疗后,观察组患者TC(2.87±0.18)mmol/L、TG(1.42±0.66)mmol/L、LDL-C(2.87±0.20)mmol/L均低于对照组(3.37±0.32)、(2.63±0.71)、(3.37±0.27)mmol/L,HDL-C(1.56±0.23)mmol/L高于对照组的(1.30±0.27)mmol/L,差异均具有统计学意义(P<0.05)。观察组不良反应发生率6.45%(2/31)低于对照组的25.81%(8/31),差异具有统计学意义(P<0.05)。结论缺血性脑卒中患者应用阿托伐他汀联合阿司匹林治疗可显著改善其病情和生理功能,且治疗安全性较高。

Objective To analyze the effect of atorvastatin combined with aspirin in the treatment of ischemic stroke.Methods A total of 62 patients with ischemic stroke were divided into observation group and control group by the lottery method,with 31 cases in each group.The control group was treated with aspirin,and the observation group was treated with atorvastatin on the basis of the control group.Both groups were compared in terms of therapeutic effect,occurrence of adverse reactions(dizziness,vomiting,confusion,gastrointestinal discomfort,etc.),and National Institutes of Health Stroke Scale(NIHSS)scores,Barthel index,and lipid[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)]levels before and after treatment.Results The total effective rate of treatment was 93.55%in the observation group,which was higher than 70.97%in the control group,and the difference was statistically significant(P<0.05).After treatment,the NIHSS score(7.66±1.24)points in the observation group was lower than(14.40±2.55)points in the control group,and the Barthel index score(82.01±3.10)points was higher than(57.54±2.60)points in the control group,and the differences were statistically significant(P<0.05).After treatment,the observation group had TC of(2.87±0.18)mmol/L,TG of(1.42±0.66)mmol/L and LDL-C of(2.87±0.20)mmol/L,which were lower than(3.37±0.32),(2.63±0.71)and(3.37±0.27)mmol/L in the control group;HDL-C(1.56±0.23)mmol/L in the observation group was higher than(1.30±0.27)mmol/L in the control group;the differences were statistically significant(P<0.05).The incidence of adverse reactions was 6.45%(2/31)in the observation group,which was lower than 25.81%(8/31)in the control group,and the difference was statistically significant(P<0.05).Conclusion Atorvastatin combined with aspirin can significantly improve the condition and physiological function of patients with ischemic stroke,and has a high treatment safety.