呋喃丹致畸性研究

Studies on Teratogenicity of Furadan

以不同剂量呋喃丹通过饮水给予在组织和器官分化危险期的不同品系大鼠23头,孕小鼠54头,每个实验均设相应的自然对照和高剂量维生素A致畸的阳性对照,共用大鼠61头,小鼠 124头,给S.D.大鼠70ppm呋喃丹剂量,超过国际类似实验,结果在给呋喃丹大鼠的260个和小鼠的517个仔鼠中,未见有超过自然对照的平均胚胎吸收数和死胎数,亦未见在外观、内脏和骨骼方面的任何畸形。在三个呋喃丹加工厂,对怀孕女190人进行流行病学调查,也未发现呋喃丹有明显的致畸作用。

54 pregnant mice and 23 pregnant rats of strains were fed with Furadan in drinking water ( 3 ppm or 8 ppm for mice and 60 or 70 ppm for rats ) during the period of organogenesis. No organ malformation was found in 517 and 260 respective term-fetus. No increase in the absorption or death of fetuses was observed as compared with natural controls. No deformity of external appearance, internal organs or skeleton was observed in the progeny of Furadan treated pregnant rats or mice. Epidemiological survey of 90 femalworkers exposed to Furadan during pregnancy did not show evidence of its teratogenic effect.