静息态功能磁共振成像在卒中后失语中的应用

Application of resting state functional magnetic resonance imaging in post-stroke aphasia

卒中后失语是一种获得性语言障碍,可严重影响日常交流并导致长期残疾。以往研究多局限于脑形态学变化,难以揭示失语后脑组织的功能变化。静息态功能磁共振成像(resting-state functional magnetic resonance imaging, rs-fMRI)能观察各脑区及脑网络的功能变化。文章回顾了利用rs-fMRI探讨失语发病和恢复机制以及治疗前后脑功能变化的文献,以期为卒中后失语的神经重塑机制提供有价值的信息并指导更精准的治疗。

Post-stroke aphasia(PSA)is an acquired language disorder,which can seriously affect daily communication and lead to long-term disability.Previous studies were mostly limited to the changes of brain morphology,and it was difficult to reveal the functional changes of brain tissue after aphasia.Resting-state functional magnetic resonance imaging(rs-fMRI)can observe the functional changes of brain regions and brain networks.This article reviews the literature on the use of rs-fMRI to explore the pathogenesis and recovery mechanism of aphasia and the changes of brain function before and after treatment,in order to provide valuable information on the neural remodeling mechanism of PSA and guide more accurate treatment.