脑深髓静脉与脑小血管病

Deep medullary veins and cerebral small vessel disease

脑小血管病(cerebral small vessel disease,CSVD)是指各种病因作用于脑小动脉、微动脉、小静脉及毛细血管所致的一系列病理、影像及临床综合征。CSVD的主要影像学特征包括脑白质高信号、脑微出血、腔隙性脑梗死、血管周围间隙扩大和脑萎缩。脑深髓静脉(deep medullary veins,DMVs)是侧脑室周围的实质小静脉,参与从脑深部白质静脉到室管膜下静脉的静脉回流。近年来,越来越多的研究显示DMVs与CSVD的发生和发展密切相关。文章对DMVs在CSVD中的作用进行了综述,为进一步探索CSVD的发病机制和影像学标志物提供思路。

Cerebral small vessel disease(CSVD)refers to a series of pathological,imaging and clinical syndrome caused by various etiologies affecting cerebral arterioles,venules and capillaries.The main imaging features of CSVD include white matter hyperintensities,cerebral microbleeds,lacunar cerebral infarction,enlarged perivascular space,and brain atrophy.Deep medullary veins(DMVs)are small parenchymal veins around the lateral ventricle,which participate in the venous return from deep white matter veins to subependymal veins.In recent years,more and more studies have shown that DMVs are closely associated with the occurrence and development of CSVD.This article reviews the role of DMVs in CSVD,and provides ideas for further exploring the pathogenesis and imaging markers of CSVD.