手性拆分--化学拆分法的研究进展

Chiral resolution--Research progress of chemical resolution

综述了近年来化学拆分法的研究进展,重点分析了经典成盐拆分法、包结拆分法和组合拆分法三种拆分方法的研究进展以及各个拆分方法的优缺点。并对化学拆分法进行了总结和展望,在未来,随着高端化学品高纯度生产的需求,对于手性化合物的光学纯度要求也越来越高,化学拆分法由于操作简单、成本低、易于大规模生产等优势而广泛应用于对映异构体的拆分,在手性拆分领域将发挥重要、不可替代的作用。

The research progress of chemical resolution in recent years is reviewed,and the research progress of classical salt formation resolution,inclusion resolution and combination resolution are emphatically analyzed,as well as the advantages and disadvantages of each resolution,and finally summarizes and prospects the chemical resolution method.In the future,with the demand of high purity production of high-end chemicals,the optical purity requirements for chiral compounds will be higher and higher.Due to its advantages of simple operation,low cost and easy mass production,chemical resolution is widely used in the separation of enantiomers,and will play an important and irreplaceable role in chiral resolution.