IL-34对Th17细胞及其细胞因子在慢性鼻-鼻窦炎调节机制中的研究前景

The research prospect of IL-34 on Th17 cells and their cytokines in the regulation mechanism of chronic rhinosinusitis

慢性鼻-鼻窦炎(chronic rhinosinusitis,CRS)是一种慢性炎症性疾病,由多种炎性细胞参与,其病程大于12周,主要临床表现为黏性或黏脓性鼻涕、鼻塞、头痛、嗅觉丧失或减退,使得患者的生活质量受到了很大的变化。目前临床上一般将CRS分为慢性鼻-鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)和慢性鼻-鼻窦炎不伴鼻息肉(chronic rhinosinusitis without nasal polyps,CRSsNP)。在炎症反应过程中,辅助性T淋巴细胞(Th)类细胞因子是最主要的一类细胞因子,Th细胞及其所产生的细胞因子在其炎症的发展过程中都起到了关键性的作用。CRS的发病机制目前为止还未完全阐释清楚,本文将对IL-34(interleukin-34,IL-34)、Th17细胞极其相关细胞因子在慢性鼻-鼻窦炎发病机制中的研究前景做一综述。

Chronic rhinosinusitis(CRS)is a chronic inflammatory disease involving a variety of inflammatory cells.The course of disease is more than 12 weeks.The main clinical manifestations are sticky or sticky purulent nasal discharge,nasal congestion,headache,loss of smell or hypoxia,which greatly changes the quality of life of patients.At present,CRS is generally divided into chronic rhinosinusitis with nasal polyps(CRSwNP)and chronic rhinosinusitis without nasal polyps Nasal polyps,(CRSsNP).In the process of inflammation,helper T lymphocyte(Th)cytokines are the most important type of cytokines.Th cells and the cytokines produced by Th cells play a key role in the development of inflammation.The pathogenesis of CRS has not been fully explained so far.In this paper,we will review the research prospects of INTERleukin-34(IL-34),Th17 cells and related cytokines in the pathogenesis of chronic rhinosinusitis.