摘要
代谢紊乱在不同类型糖尿病的发病和进展中发挥重要作用。代谢组学研究的是基因和蛋白的终端表达产物,在后基因组时代,基于代谢组学的生物标志物及代谢通路研究正在不断“重写”疾病的病因学,成为探索致病机制和精准诊疗的前沿。本文对不同类型糖尿病的代谢组学及精准医学研究最新进展进行简要综述。
Objective Metabolic disturbances play a crucial role in the occurrence and progression of different types of diabetes.Metabolomics is the study of terminal products of genes and proteins,in the post-genomic era,metabolomics studies on biomarker and metabolic pathway are rewriting the etiology and emerging as a frontier for exploring pathogenic mechanisms and precision medicine.In this paper,the current progress of metabolomics and precision medicine research for different types of diabetes were reviewed.
作者
蒋燕燕
李建华
吴聪
董捷
孙志
陈素芳
JIANG Yanyan;LI Jianhua;WU Cong;DONG Jie;SUN Zhi;CHEN Sufang(Department of Geriatric Endocrinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Emergency Intensive Care Ward,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Henan Engineering Research Center of Clinical Mass Spectrometry for Precision Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《河南医学研究》
CAS
2023年第6期1148-1152,共5页
Henan Medical Research
基金
2022年度河南省卫健委联合共建项目(LHGJ20220307)
河南省中青年卫生健康科技创新优秀人才培养项目(YXKC2020058)
河南省高等学校重点科研项目(20A320030)。
关键词
糖尿病
代谢组学
精准医学
生物标志物
diabetes mellitus
metabolomics
precision medicine
biomarker
