黄连提取物抗阿尔茨海默病的研究进展

Research progress on the use of Rhizoma coptidis extract against Alzheimer's disease

黄连提取物具有多种药理活性,包括改善阿尔茨海默病(AD)的认知障碍,其抗AD的主要机制为减少β-淀粉样蛋白(Aβ)的产生、抑制Tau蛋白磷酸化、抑制胆碱酯酶、抗炎、抗氧化、改善细胞凋亡等。本文对黄连提取物的抗AD作用及具体机制进行综述,为相关研究和临床应用提供理论依据。

Rhizoma coptidis extract has a variety of pharmacological activities,including alleviating cognitive impairment in Alzheimer's disease(AD).The main mechanisms of its anti-AD activity include reducing the production of amyloid β(Aβ),inhibiting the phosphorylation of Tau protein,inhibiting cholinesterase,anti-inflammation,anti-oxidation,improving apoptosis,etc.This paper reviewed the anti-AD effect of Rhizoma coptidis extract and the specific mechanisms,aiming to provide a theoretical basis for relevant research and clinical practice.