肾上腺皮质激素联合孟鲁司特钠治疗小儿过敏性紫癜的效果及对症状消失时间和炎症因子的影响

Effect of Adrenal Corticosteroids and Montelukast Sodium in the Treatment of Pediatric Allergic Purpura and Its Influence on the Disappearance Time of Symptoms and Inflammatory Factors

目的:探讨肾上腺皮质激素联合孟鲁司特钠治疗小儿过敏性紫癜的效果及对症状消失时间和炎症因子的影响。方法:选取2020年2月-2022年5月景德镇市妇幼保健院收治的64例过敏性紫癜患儿,按照随机数字表法将其分为两组,各32例。两组入院后均接受常规检查,对照组采用常规治疗+肾上腺皮质激素治疗,观察组在对照组基础上加用孟鲁司特钠,2周为1个疗程,两组患儿均持续治疗2个疗程。比较两组临床疗效、症状消失时间、炎症因子[降钙素原(PCT)、白介素-6(IL-6)、C反应蛋白(CRP)]水平及不良反应发生情况。结果:观察组治疗总有效率为93.75%,高于对照组的71.88%,差异有统计学意义(P<0.05)。观察组消化道症状消失时间、皮肤症状消失时间、肾脏症状消失时间、关节症状消失时间均短于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组PCT、IL-6、CRP水平均低于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在过敏性紫癜患儿中应用肾上腺皮质激素联合孟鲁司特钠治疗能够有效缓解患儿病情,有效抑制炎症反应,疗效确切,安全可靠,值得推广。

Objective:To investigate the effect of adrenal corticosteroids and Montelukast Sodium in treatment of pediatric allergic purpura and its influence on the disappearance time of symptoms and inflammatory factors.Method:A total of 64 children with allergic purpura admitted to Jingdezhen Maternal and Child Health Hospital from February 2020 to May 2022 were selected,they were divided into two groups by random number table method,32 cases in each group.Both groups received routine examination after admission,the control group was treated with conventional treatment and adrenal corticosteroids treatment,while the observation group was treated with Montelukast Sodium on the basis of the control group,2 weeks as a course of treatment,and both groups were treated continuously for 2 courses of treatment.The clinical efficacy,disappearance time of clinical symptoms,levels of inflammatory factors[procalcitonin(PCT),interleukin-6(IL-6),C reactive protein(CRP)]and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was 93.75%,which was higher than 71.88%of the control group,the difference was statistically significant(P<0.05).The disappearance time of gastrointestinal symptoms,skin symptoms,kidney symptoms and joint symptoms of the observation group were shorter than those of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of PCT,IL-6 and CRP of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The application of adrenal corticosteroids and Montelukast Sodium in the treatment of children with allergic purpura can effectively relieve the condition of children,effectively inhibit the inflammatory reaction,effective,safe and reliable,worthy of promotion.