铁死亡在子宫内膜癌中的作用研究概述

Advances in the Roles of Ferroptosis in Endometrial Cancer

铁死亡是近年来提出的一种新型细胞死亡形式,以铁超载和活性氧聚集为特征。越来越多的证据表明,铁死亡与肿瘤的发生发展相关。而肿瘤微环境是肿瘤细胞增殖、分化等活动所需的环境。本文将根据铁死亡的概念、机制以及其在子宫内膜癌中的作用进行综述,为子宫内膜癌的临床治疗提供新思路。

Ferroptosis is a newly proposed form of cell death in recent years,characterized by iron overload and accumulation of reactive oxygen species.There is increasing evidence that ferroptosis is associated with the occurrence and development of tumors.The tumor microenvironment is the environment required for the proliferation,differentiation and other activities of tumor cells.This article will review the concept and the mechanism of ferroptosis and its role in endometrial cancer,hoping to provide new ideas for the clinical treatment of endometrial cancer.