清肠汤联合心身同治疗法对热盛血瘀型溃疡性结肠炎HGF/c-MET表达的影响

Effect of Qingchang Decoction(清肠汤)Combined with Psychosomatic Treatment on Expression of HGF/c-MET in Patients with Ulcerative Colitis of Heat Hyperactivity and Blood Stasis Type

目的探讨清肠汤联合心身同治疗法对热盛血瘀型溃疡性结肠炎患者肝细胞生长因子(hepatocyte growth factor,HGF)/肝细胞生长因子受体(cellular-mesenchymal to epithelial transition factor,c-MET)表达影响。方法选取于2019年5月—2021年5月医院内科门诊确诊的热盛血瘀型溃疡性结肠炎(ulcerative colitis)患者146例,根据前瞻队列研究按照1∶1原则分为对照组与研究组两组,每组73例。对照组给予口服美沙拉嗪缓释颗粒,4 g/d,治疗组在对照组治疗基础上给予清肠汤和心身同治疗法。两组患者治疗疗程均为3个月,治疗结束后随访3个月,治疗后评价两组患者疗效,分析治疗前后两组患者的中医症状积分(腹泻、黏液脓血便、腹痛、里急后重)和肠黏膜组织HGF、c-MET的免疫组化结果。结果经比较,治疗后研究组患者治疗总有效率(97.26%,71/73)显著高于对照组(86.30%,63/73),差异具有统计学意义(P<0.05)。两组腹泻、黏液脓血便、腹痛、里急后重中医症状积分均显著降低(P<0.05),但研究组治疗后各症状积分及总积分均显著低于对照组(P<0.05)。经治疗后,两组HGF及c-MET阳性率均显著增高(P<0.05),但研究组HGF及c-MET阳性率均显著高于对照组(P<0.05)。结论清肠汤联合心身同治疗法对热盛血瘀型溃疡性结肠炎具有较好的临床疗效,可以提高肠黏膜组织上的HGF/c-MET的表达。

Objective To explore the effect of Qingchang Decoction(清肠汤)combined with psychosomatic treatment on the expression of hepatocyte growth factor(HGF)/cellular-mesenchymal to epithelial transition factor(c-Met)in patients with ul⁃cerative colitis of heat hyperactivity and blood stasis type.Methods A total of 146 patients with UC of heat hyperactivity and blood stasis type diagnosed in the internal medicine clinic of the hospital from May 2019 to May 2021 were selected.According to the prospective cohort study,they were divided into control group and study group according to the principle of 1∶1,with 73 cases in each group.The control group was given oral mesalazine sustained-release granules,4 g/d.The study group was given Qingchang Decoction and psychosomatic treatment on the basis of the treatment of the control group.The treatment course of the two groups was 3 months,and the patients were followed up for 3 months after the treatment.The therapeutic effects of the two groups were evaluated after treatment.The TCM symptom scores(diarrhea,mucopurulent bloody stool,abdominal pain,tenesmus)and the immunohistochemical results of HGF and c-Met in intestinal mucosa were analyzed before and after the treatment.Re⁃sults After treatment,the total treatment efficiency of the study group(97.26%,71/73)was significantly higher than that of the control group(86.30%,63/73).The difference was statistically significant(P<0.05).The TCM symptom scores of diarrhea,mucopurulent bloody stool,abdominal pain,tenesmus in the two groups were significantly lower(P<0.05),but the symptom scores and total scores in the study group were significantly lower than those in the control group(P<0.05).After treatment,the positive rates of HGF and c-Met in the two groups were significantly higher(P<0.05),but the positive rates of HGF and c-Met in the study group were significantly higher than those in the control group(P<0.05).Conclusions Qingchang Decoction combined with psychosomatic treatment has a good clinical effect on ulcerative colitis of heat hyperactivity and blood stasis type,and can improve the expression of HGF/c-Met in intestinal mucosa.