基于中医气血理论探究AMPK/mTOR信号通路与自噬的关系

Research on Relationship between AMPK/MTOR Signal Pathway and Autophagy Based on Theory of Qi and Blood in Traditional Chinese Medicine

自噬是机体清除自身衰老细胞及有害物质的一种维持细胞能量稳态平衡的机制,受营养因素影响明显,AMPK/mTOR是感受能量变化以调节自噬的重要信号通路。中医学认为气血是水谷精微化生的一种构成人体的基本物质,气血关系是机体能量代谢的微观体现。气的推动、调控、温煦、凉润、防御和中介等作用与自噬维持机体各系统正常运转的作用高度相似,而血的濡养作用又与自噬受能量影响相似,因此AMPK/mTOR是调节自噬的重要途径,气血关系是维持自噬稳态的重要物质基础,气血理论是AMPK/mTOR通路调控自噬的重要理论基础。

Autophagy,as a system of maintaining the banlance of cell energy and removing harmful substance from intracellular environment,is obviously affected by nutritional factors.AMPK/mTOR is an signal pathway which plays an important role in sensing the changes of energy and regulating the functions of autophagy.Traditional Chinese medicine believes that Qi and blood are the basic substances that constitute the human body and the relationship between Qi and blood is the microcosmic manifestation of the energy metabolism of the body.The functions of autophagy are highly similar to the effects of Qi in promoting,regulating,warming,cooling,defending,mediating and the blood nourishing function is closely related to the autophagy significantly by nutritional factors.Therefore,AMPK/mTOR is an important way to regulate autophagy.The relation of Qi and blood is an important material basis of autophagy.Qi and blood theory of TCM is an important theoretical basis of regulating autophagy.