摘要
Osteoarthritis(OA)is the most common chronic disease,characterized by progressive cartilage breakdown,subchondral bone sclerosis,and aberrant bone outgrowth(Yucesoy et al.,2015;Hussain et al.,2016).OA is one of the leading causes of cartilage damage.Patients with severe cartilage damage require transplantation of articular cartilage to improve their quality of life.Type Ⅱ collagen is a major component of articular cartilage and intervertebral discs and plays an important role in the structure and strength of connective tissues that support muscles and joints(Byers,1994).
基金
financially supported by National Key Research and Development Program of China(2017YFA0105103)
the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030503)
Key Research&Development Program of Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)(2018GZR110104004)
Science and Technology Planning Project of Guangdong Province,China(2020B1212060052,2017A050501059)
Science and Technology Program of Guangzhou,China(202007030003)
Research Unit of Generation of Large Animal Disease Models,Chinese Academy of Medical Sciences(2019-I2M-5-025)
the Science Foundation for Young Teachers of Wuyi University(2019TD05)
Natural Science Foundation of Guangdong Province of China(2019A1515110283)
Jiangmen Science and Technology Plan Project(2020JC01030)。
