中医药干预NF-κB信号通路防治高血压靶器官损伤的实验研究进展

Experimental research progress of Chinese medicine intervention in NF-κB signaling pathway to prevent and treat target organ damage in hypertension

高血压是多种心血管疾病的重要危险因素之一,长期持续血压升高可导致心、脑、肾、血管等靶器官的损伤,且其患病率及致残率呈不断攀升趋势。高血压靶器官损伤过程与免疫炎症失调相关,而核因子κB(nuclear factor-κB,NF-κB)是介导炎症反应的枢纽。NF-κB信号通路是中医药防治高血压靶器官损伤的重要靶点之一。对近5年来国内外中药单体及其有效成分、复方制剂、针灸作用于NF-κB信号通路而防治高血压所致心、脑、肾及血管等靶器官损伤的实验研究进行综述,旨在为中医药防治高血压靶器官损伤提供新的理论依据与思路。

Hypertension is one of the important risk factors for many cardiovascular diseases.The prolonged high blood pressure can cause damage to target organs such as the heart,brain,kidneys and blood vessels,and its prevalence and disability rate are increasing.The damage of target organ for hypertension patients is related to the imbalanced immune inflammation,and nuclear factor-κB(NF-κB)is the hub of mediating inflammatory response.NF-κB signaling pathway is one of the important target sites of Chinese medicine in preventing and treating target organ damage of hypertension cases.This paper has reviewed the researches in the past five years on the prevention and treatment of target organ(heart,brain,kidneys,blood vessels etc.)damage due to hypertension by the way that Chinese medicine monomer and its effective components,compound preparations and acupuncture acts on NF-κB signaling pathway.It aims to provide new theoretical bases and ideas for preventing and treating target organ damage of hypertension with Chinese medicine.