智能可逆药物递送系统的研究进展

Research progress of intelligent reversible drug delivery system

在癌症诊疗相关研究中,大部分环境敏感型药物递送系统在病理条件下仅能实现单向、不可逆的响应性改变,可在一定程度上提高递送系统的靶向效果和释药性能。但是,当动态分布的递送系统回流到血液循环或转运至正常生理环境时,这种不可逆的变化会带来潜在的安全隐患。智能可逆药物递送系统则可以响应正常生理和病理微环境,实现结构上的双向、可逆改变。这一特征将有助于精准控制递送系统的药物释放、延长血液循环时间,进而提高靶向效率,避免不可逆药物递送系统的安全隐患。本综述从控制药物释放和延长血液循环时间、增强细胞内化两个主要方面,对智能可逆药物递送系统的研究进展进行分述。

In the research on cancer theranostics,most environment-sensitive drug delivery systems can only achieve unidirectional and irreversible responsive changes under pathological conditions,thereby improving the targeting effect and drug release performance of the delivery system.However,such irreversible changes pose potential safety hazards when the dynamically distributed delivery system returns to the blood circulation or transports to the normal physiological environment.Intelligent reversible drug delivery systems can respond to normal physiological and pathological microenvironments to achieve bidirectional and reversible structural changes.This feature will help to precisely control the drug release of the delivery system,prolong the blood circulation time,improve the targeting efficiency,and avoid the potential safety hazards of the irreversible drug delivery system.In this review,we describe the research progress of intelligent reversible drug delivery system from two main aspects:controlled drug release and prolonged blood circulation time/enhanced cellular internalization of drug.