智能响应型介孔二氧化硅抗肿瘤纳米递药系统的设计策略与研究应用

Application research and design strategy on smart responsive mesoporous silica anti-tumor nanodelivery systems

恶性肿瘤是危害人类健康的重大疾病,由于其微环境复杂多变,导致大多数抗肿瘤药物不能精准地到达病灶组织并可控释放。智能响应型纳米载体已成为抗肿瘤递药系统研究领域的热点。介孔二氧化硅作为一种优良的纳米材料,具有无毒、稳定、孔容孔径可调及表面易于功能化修饰等优势,凭借其对机体肿瘤微环境或生理变化的感知响应、实现递药系统在病灶组织定位释药或控制释药,使其成为智能响应型递药系统的理想载体。本文基于介孔二氧化硅的智能响应型递药系统的设计策略及研究应用展开综述,以期为抗肿瘤药物纳米制剂的研发提供参考。

Malignant tumors are major diseases that endanger human health.Due to their complex and variable microenvironment,most anti-tumor drugs cannot precisely reach the focal tissue and be released in a controlled manner.Intelligent responsive nano carriers have become a hot spot in the field of anti-tumor drug delivery systems.As an excellent nano material,mesoporous silica has the advantages of non-toxic,stable,adjustable pore volume and pore diameter,and easy functional modification on the surface.By virtue of its perceptive response to the tumor microenvironment or physiological changes,it can achieve the targeted drug release or controlled drug release of the drug delivery system in the tissue,making it an ideal carrier for intelligent response drug delivery system.In this paper,we review the design strategies and current research status of smart responsive anti-tumor drug delivery systems based on mesoporous silica,in order to provide a reference for the development of antitumor drug nanoformulations.