胰岛素样生长因子2 mRNA结合蛋白2基因与2型糖尿病相关性的研究进展

Research progress in correlation between insulin-like growth factor 2 mRNA binding protein 2 gene and type 2 diabetes mellitus

2型糖尿病(type 2 diabetes mellitus,T2DM)是一种多基因遗传和环境因素共同作用的慢性、非传染性疾病,其主要特征包括胰岛素抵抗和胰岛素分泌不足。胰岛素样生长因子2 mRNA结合蛋白2(insulin-like growth factor 2 mRNA binding protein 2,IGF2BP2/IMP2)作为机体一种重要的胰岛素分泌相关蛋白,其主要在胰腺、脂肪和肠道等组织细胞中表达,IGF2BP2被证实可下调IGF2的表达,与其有关的胰岛β细胞功能破坏是T2DM及血管并发症的重要原因,因此,IGF2BP2基因可作为预测糖尿病风险的重要因子之一。本文就IGF2BP2基因与T2DM之间的相关性作一综述。

Type 2 diabetes mellitus(T2DM)was a chronic,non-communicable disease with a combination of multiple genetic and environmental factors,of which the main characteristics included insufficient insulin secretion and insulin resistance.Insulin-like growth factor 2 mRNA binding protein 2(IGF2BP2/IMP2),an important insulin secretion-related protein in human body,is mainly expressed in tissues and cells such as pancreas,fat and intestine.It has been confirmed that IGF2BP2 can down-regulate the expression of IGF2 and the function damage of the related islet β cell is an important cause of T2DM and vascular complications.Therefore,IGF2BP2 gene can be used as an important predictor for diabetes mellitus risk.This paper reviews the correlation between IGF2BP2 gene and T2DM.