基于人体成分的生活方式干预对PCOS的临床效果研究

Clinical effect of body composition based lifestyle intervention on polycystic ovary syndrome

目的 研究基于人体成分的生活方式干预方法对多囊卵巢综合征(polycystic ovary syndrome, PCOS)患者的临床治疗效果。方法 选取2020年11月至2021年7月乌鲁木齐市第一人民医院妇科确诊的PCOS患者100例作为研究对象(失访9例)。采用前瞻性随机对照病例研究,将患者随机分为试验组(45例)和对照组(46例),对照组单纯采用屈螺酮炔雌醇片(Ⅱ)干预,试验组在对照组基础上联合基于人体成分的生活方式共同干预,比较两组患者治疗3个月前后的各项指标变化。结果 两组PCOS患者治疗前各人体成分及(生殖)内分泌指标比较差异无统计学意义(P>0.05)。治疗后,两组患者总体水、细胞内液、总体细胞外液、体脂百分比、脂肪量及去脂体重均降低,体重、腰围、体质量指数(body mass index, BMI)、睾酮(testosterone, T)及促黄体生成素(luteinizing hormone, LH)水平均降低,空腹血糖(fasting plasmaglucose, FPG)、空腹胰岛素(fsating insulin, FIN)、甘油三酯(triglyceride, TG)、总胆固醇(total cholesterol, TC)及低密度脂蛋白(low-density lipoprotein, LDL-C)均降低,且试验组降低更显著(P<0.05)。两组患者基础代谢率、肌肉重、促卵泡生成素(follicle-stimulating hormone, FSH)、高密度脂蛋白(high-density lipoprotein, HDL-C)比较,差异无统计学意义(P>0.05)。试验组患者发生自主排卵和妊娠成功明显升高,两组比较差异有统计学意义(P<0.05)。结论 基于人体成分的生活方式干预能有效改善PCOS患者内分泌代谢,促进排卵,提高妊娠率,具有较好的临床价值。

Objective To investigate the clinical effect of human component-based lifestyle intervention on patients with polycystic ovary syndrome(PCOS).Methods A total of 10O PCOS patients diagnosed in the Department of Gynecology of Urumqi First People's Hospital from November 2020 to July 2021 were selected as research objects(9 cases lost to follow-up).Using prospective randomized controlled case study,patients were randomly divided into experimental group(45 cases)and control group(46 cases),the control group simply using drospirosterone ethinylestradiol tablets(Ⅱ)intervention,the experimental group based on the control group combination of human body composition of the lifestyle intervention,compared the two groups of patients before and after 3 months of treatment of the index changes.Results There was no significant difference in body composition and(reproductive)endocrine indexes between two groups before treatment(P>0.05).After treatment,total water,intracellular fluid,total extracellular fluid,body fat percentage,fat mass and fat-free body weight were decreased in both groups,body weight,waist circumference,body mass index(BMI),testosterone(T),and luteinizing hormone(LH)levels were decreased,fasting plasmaglucose(FPG),fasting insulin(FIN),triglyceride(TG),total cholesterol(TC)and low density lipoprotein(LDL-C)were decreased,and the reduction was more significant in the experimental group(P<0.05).Basal metabolic rate,muscle weight,follicle-stimulatinghormone(FSH)and highdensity lipoprotein(HDL-C)were not significantly different between the two groups(P>O.05).The spontaneous ovulation and pregnancy success of the experimental group were significantly increased,and the difference between the two groups was statistically significant(P<0.05).Conclusion Lifestyle intervention based on body composition can effectively improve endocrine metabolism,promote ovulation and improve pregnancy rate in patients with PCOS,which has good clinical value.