肿瘤相关巨噬细胞在多发性骨髓瘤中作用的研究进展

Research Progress on the Role of Tumor-Associated Macrophages in Multiple Myeloma——Review

骨髓微环境是肿瘤周围高度复杂的环境,在多发性骨髓瘤(MM)细胞存活、增殖、耐药、迁移等方面具有重要作用。肿瘤相关巨噬细胞(TAM)作为肿瘤微环境中重要的细胞成分,由于在肿瘤进展和耐药等方面发挥关键作用而受到关注。靶向TAM在癌症治疗中已显示出潜在的价值。为了明确巨噬细胞在MM进展中的作用,有必要了解TAM分化及其促进MM的特性。本文对TAM在MM中如何编程及促进肿瘤发展和耐药的机制研究进展作一综述。

Bone marrow microenvironment is a highly complex environment surrounding tumor,which plays an important role in the survival,proliferation,drug resistance and migration of multiple myeloma(MM)cells.As an important cellular component in tumor microenvironment,tumor-associated macrophages(TAM)has attracted attention due to its key role in tumor progression and drug resistance.Targeting TAM has shown potential therapeutic value in cancer treatment.In order to clarify the role of macrophages in MM progression,it is necessary to understand the differentiation of TAM and its characteristics of promoting MM.This paper reviews the research progress on how TAM is programmed in MM and the mechanism of TAM promoting tumor development and drug resistance.