盘状结构域受体1(DDR1):实体肿瘤治疗的新靶点

Discoidin domain receptor 1(DDR1):a new drug target for solid tumors

盘状结构域受体家族(discoidin domain receptors,DDRs)成员DDR1广泛表达于人体正常组织,与肿瘤的发生发展密切相关,基于DDR1本身的结构和生物学特点,围绕DDR1在肿瘤研究的进展展开综述,阐述DDR1对肿瘤细胞的增殖生存、迁移侵袭、上皮间质转化和细胞代谢的影响,以及DDR1对肿瘤微环境的重要作用,同时分析以DDR1为靶点的抗肿瘤药物的研究进展,以期为DDR1作为实体肿瘤治疗的新靶点提供理论依据和临床参考。

DDR1,a member of the discoidin domain receptor family(DDRs),is widely expressed in human normal tissues and is closely related to the genesis and development of tumors.Based on the structure and biological characteristics of DDR1,this paper reviews the research progress of DDR1 in tumor,expounds the effects of DDR1 on tumor cell proliferation,survival,migration,invasion,epithelial interstitial transformation,and cell metabolism,as well as the important role of DDR1 in tumor microenvironment,and summarizes the progress of anti-tumor drugs targeting DDR1.The study aims to provide theoretical basis and clinical reference for DDR1 as a new target for solid tumor therapy in the future.