癫痫患者血清CyPA、FGL2水平、脑电图异常与认知功能的关系

The relationship between serum CyPA,FGL2 levels,EEG abnormality and cognitive function in patients with epilepsy

目的探讨癫痫患者血清亲环素A(CyPA)、纤维蛋白原样蛋白2(FGL2)、脑电图异常与认知功能的关系。方法选取本院2019年4月-2022年4月收治的癫痫患者116例为研究对象,另选取同期本院体检的健康对照者116例作为对照。并根据脑电图结果分为脑电图正常组和异常组,异常组再分为轻度组、中度组及重度组。检测血清FGL2、CyPA水平,分析血清FGL2、CyPA水平、脑电图异常程度与认知功能的相关性。结果癫痫组癫痫发作1 h、24 h血清FGL2、CyPA水平高于对照组(P<0.05);癫痫发作24 h时患者血清FGL2、CyPA水平低于发作1 h时(P<0.05)。癫痫发作1 h、24 h异常组患者血清FGL2、CyPA水平高于癫痫发作1 h、24 h正常组(P<0.05)。癫痫发作1 h、24 h重度组血清FGL2、CyPA水平高于癫痫发作1 h、24 h中度组、轻度组,中度组亦高于轻度组(P<0.05)。癫痫组MoCA评分总分及各项评分低于对照组(P<0.05)。癫痫发作1 h、24 h血清FGL2、CyPA水平、脑电图异常程度均与癫痫患者MoCA评分呈负相关(P<0.05)。结论癫痫患者血清FGL2、CyPA水平均高表达,随脑电图异常程度加重逐渐增高,且血清FGL2、CyPA水平及脑电图异常与癫痫患者的认知功能密切相关。

Objective To investigate the relationship between serum cyclophilin A(CyPA),fibrinogen like protein 2(FGL2),electroencephalogram(EEG)abnormality and cognitive function in patients with epilepsy.Methods A total of 116 epileptic patients admitted to our hospital from April 2019 to April 2022 were selected as the study subjects,in addition,116 healthy controls from the same period were selected as controls.Patients were divided into normal EEG group and abnormal EEG group according to EEG results,and the abnormal EEG group was grouped into mild group,moderate group and severe group.Serum FGL2 and CyPA levels were detected,the correlation between serum FGL2,CyPA levels,abnormal degree of EEG and cognitive function were analyzed.Results The levels of serum FGL2 and CyPA in epileptic group at 1 h and 24 h after seizure higher than those in control group(P<0.05);the levels of serum FGL2 and CyPA at 24 hours of seizure lower than those at 1 hour of seizure(P<0.05).The levels of serum FGL2 and CyPA in patients with abnormal seizure for 1 h and 24 h higher than those in normal seizure for 1 h and 24 h(P<0.05).The levels of serum FGL2 and CyPA in the severe group at 1 h and 24 h after seizures higher than those in the moderate and mild groups at 1 h and 24 h after seizures,and those in the moderate group were higher than those in the mild group(P<0.05).The total score and each score of MoCA in epilepsy group lower than those in control group(P<0.05).The levels of serum FGL2,CyPA and abnormal degree of EEG negatively correlated with MoCA score of epileptic patients at 1 h and 24 h after seizures(P<0.05).Conclusion The levels of serum FGL2 and CyPA in epileptic patients are highly expressed,and gradually increase with the aggravation of EEG abnormalities.The levels of serum FGL2,CyPA and EEG abnormality are closely related to the cognitive function of epileptic patients.