钙离子/钙调素依赖性蛋白激酶Ⅱ在心肾综合征中的作用

Role of Calcium Ion/Calmodulin-dependent Protein Kinase II in Cardiorenal Syndrome

钙离子/钙调素依赖性蛋白激酶(CaMK)是健康与疾病中钙离子信号传导的重要调节因子。钙离子/钙调素依赖性蛋白激酶Ⅱ(CaMKⅡ)是其最丰富的亚型,主要分布于心脏,通常被认为是兴奋收缩偶联的调节因子。然而,最近的研究表明,其也可以介导心血管疾病(CVD)的炎症。随着全球心血管疾病合并肾脏疾病的发病率越来越高,心肾综合征(CRS)已经成为一个迫切需要解决的问题。虽然CaMKⅡ对心脏的重要性众所周知,但是CaMKⅡ对CRS的作用却知之甚少。现通过使用PubMed数据库进行广泛文献检索,旨在讨论CaMKⅡ作为一种炎症介质在心脏和肾脏两个脏器之间的相互作用。

Calcium ion/calmoduHn-dependent protein kinases(CaMKs)are important regulators of calcium ion sig-naling in health and disease.CaMKII is the most abundant subtype,is found mainly in the heart and is generally considered to be a regulator of excitation-contraction coupling.However,recent studies have shown that it can also mediate inflammation in cardiovascular diseases(CVD).With the increasing incidence of cardiovascular disease combined with kidney disease worldwide,cardiorenal syndrome(CRS)has become an urgent problem to be solved.Although the importance of CaMKII to the heart is well known,the role of CaMKII in CRS is poorly understood.The author aims to discuss the role of CaMKII as an inflammatory mediator in heart and kidney interaction by conducting an extensive literature review using the database PubMed.