巨噬细胞在棘球蚴病中的作用及虫源性分子对巨噬细胞调控的研究进展

Research progress on the role of macrophages in echinococcosis and the regulation of macrophages by parasite-derived molecules

巨噬细胞作为天然免疫的主要成员,可通过细胞吞噬、抗原提呈及免疫调节等方式或途径清除病原体,在棘球绦虫等寄生虫感染中发挥重要作用。同时,棘球绦虫幼虫(棘球蚴)可通过多种虫源性分子,如蛋白、核酸分子等,调控宿主巨噬细胞功能,实现在宿主体内的长期寄生。本文重点对巨噬细胞在棘球蚴病中的作用以及虫源性分子对巨噬细胞调控的研究进展进行综述。

As a major member of innate immunity,macrophage can eliminate pathogens through cell phagocytosis,antigen presentation and immune regulation,and play an important role in parasitic infections such as Echinococcus.Echinococcus can regulate the function of host macrophages through a variety of parasite-derived molecules,such as protein and nucleic acid molecules,and realize long-term parasitism in the host.This article focuses on the research progress of the role of macrophages in echinococcosis and the regulation of macrophages by parasite-derived molecules.