槲皮素的结构修饰及生物活性研究进展

Research progress on structural modification and biological activity of quercetin

槲皮素是蔬菜、水果、中药中常见的黄酮类化合物,是天然的抗氧化剂,具有抗癌、抗糖尿病、抗菌、抗炎、抗病毒等生物活性。由于槲皮素生物利用度低,限制了其在临床上的应用。通过各种方法设计和合成新的槲皮素衍生物,以改善其缺点,进而发挥预防和治疗疾病的作用。通过对槲皮素衍生物的合成及其抗癌、抗糖尿病、抗炎、抗菌和抗病毒活性进行综述,并对其构效关系进行分析,为天然化合物的开发和利用奠定基础。

Quercetin is a common flavonoid found in vegetables,fruits and traditional Chinese medicine.It is a natural antioxidant with anti-cancer,anti-diabetes,antibacterial,anti-inflammatory,anti-virus and other biological activities.The low bioavailability of quercetin limits its clinical application.New quercetin derivatives were designed and synthesized by various methods to improve their shortcomings and thus play a role in the prevention and treatment of diseases.By reviewing the synthesis and anti-cancer,anti-diabetes,anti-inflammatory,antibacterial and antiviral activities of quercetin derivatives,and analyzing their structure-activity relationship,we lay a foundation for the development and utilization of natural compounds.