基于脑肠轴理论探讨柴胡加龙骨牡蛎汤对癫痫患者胶质纤维酸性蛋白、神经肽Y及S100B的影响

Exploring Effects of Chaihu plus Longgu Muli Decoction(柴胡加龙骨牡蛎汤)on Glial Fibrillary Acidic Protein,Neuropeptide Y and S100B in Patients with Epilepsy Based on Brain Gut Axis Theory

目的基于脑肠轴理论探讨柴胡加龙骨牡蛎汤对癫痫患者胶质纤维酸性蛋白、神经肽Y及S100B的影响。方法纳入2018年1月—2020年1月癫痫患者114例作为观察对象,随机分为两组,对照组57例选用电子生物反馈技术;联合组57例选用柴胡加龙骨牡蛎汤联合电子生物反馈技术,持续治疗3个月。比较临床疗效及癫痫生活质量评定量表(epilepsy quality of life scale-31,QOLIE-31)、不良反应,治疗前后测定血清胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)、神经肽Y(neuropeptide Y,NPY)及S100B水平。结果对照组有效率82.46%(47/57)低于联合组94.74%(54/57),有统计学意义(P<0.05)。与治疗前比,两组治疗后血清GFAP、NPY及S100B水平均降低,而且联合组治疗后血清GFAP、NPY及S100B水平低于对照组,有统计学意义(P<0.05)。对照组综合质量、情绪、总体健康、药物影响、认知功能、社会功能、精力及对发作担忧评分低于联合组,有统计学意义(P<0.05)。两组患者不良反应率分析,无统计学意义(P>0.05)。结论柴胡加龙骨牡蛎汤有疏利肝胆,和解少阳之功,对癫痫患者的疗效显著,可以降低神经细胞因子,提高生活质量,值得推广。

Objective To investigate the effect of Chaihu plus Longgu Muli Decoction(柴胡加龙骨牡蛎汤)on glial fibrillary acidic protein,neuropeptide Y and S100B in epileptic patients based on brain-gut axis theory.Methods A total of 114 patients with epilepsy from January 2018 to January 2020 were randomly divided into two groups.Fifty-seven cases in the control group were treated with electronic biofeedback technology and the other 57 cases in the combined group were treated with Chaihu plus Longgu Muli Decoction combined with electronic biofeedback technology.The clinical efficacy,epilepsy quality of life scale-31(QOLIE-31)and adverse reactions were compared.The serum levels of glial fibrillary acidic protein(GFAP),neuropeptide Y(NPY)and S100 calcium binding protein B(S100B)were measured before and after treatment.Results The effective rate of the control group was 82.46%,which was lower than that(94.74%)of the combined group,with statistical significance(P<0.05).Compared with those before treatment,the levels of serum GFAP,NPY and S100B in the two groups were decreased after treat⁃ment,and the levels of serum GFAP,NPY and S100B in the combined group were lower than those in the control group after treat⁃ment,with statistical significance(P<0.05).The scores of comprehensive quality,emotion,overall health,drug effect,cognitive function,social function,energy and anxiety about attack in the control group were lower than those in the combined group,with statistical significance(P<0.05).The adverse reaction rate of the two groups was not statistically significant(P>0.05).Con⁃clusion Chaihu plus Longgu Muli Decoction combined with electronic biofeedback technology has a significant effect on patients with epilepsy.It can reduce nerve cytokines and improve the quality of epilepsy patients and is worthy of popularizing.