基于肠道菌群与抑木扶土理论探讨自身免疫性肝病的病机与治疗

Discussion on Pathogenesis and Treatment of Autoimmune Liver Disease Based on Intestinal Microecology and Theory of Supporting Spleen and Restricting Liver

肠道微生物通过肠-肝轴参与了自身免疫性肝病(autoimmune liver disease, AILD)的发生与发展。吕文良教授将调节肠道菌群与中医抑木扶土理论结合,探讨AILD的病机治疗。吕文良教授指出,脾气虚弱,肝气郁结,肝脾同病是AILD的发病基础,患者肠道菌群紊乱是中医脾气虚弱,脾失健运的病理表现之一。在治疗上应以抑木扶土,实脾理肝,健脾为主作为治疗大法,通过肠-肝轴改善患者肠道微生态,调节机体免疫状态,恢复肝脏正常功能。

In recent years, more and more modern medical studies have shown that intestinal microecology is involved in the pathogenesis and development of autoimmune liver disease through the enteric-hepatic axis.Professor LYU Wenliang combined the regulation of intestinal flora with the theory of supporting spleen and restricting liver in traditional Chinese medicine to explore the pathogenesis and treatment of AILD.Professor LYU Wenliang pointed out that spleen-Qi deficiency, liver-Qi depression and common diseases of liver and spleen are the basis of AILD.The disorder of intestinal flora in patients is one of the pathological manifestations of spleen-Qi deficiency and dysfunction of spleen in transportation in traditional Chinese medicine.In the treatment, we should take supporting spleen and restricting and regulating liver, strengthening spleen methods mainly as the important treatment, improve the intestinal microecology of patients through the enteric-hepatic axis, regulate the immune state of the patient and restore the normal function of liver.