基于关联规则的近现代名中医治疗皮肤瘙痒组方规律研究

Rule of Prescriptions for Treatment of Pruritus by Modern Famous Chinese Medicine Based on Association Rule

目的 基于关联规则分析近现代名中医治疗皮肤瘙痒的用药与组方规律。方法 以“痒”和“瘙痒”为主题词,检索《中国百年百名中医临床家丛书》《近代名老中医经验集》《现代著名老中医名著重刊丛》。收集方剂,录入中医传承辅助系统(V2.5版本)建立方剂数据库,采用软件集成关联规则apriori算法、复杂系统熵聚类、无监督的熵层次聚类等方法进行数据挖掘,获得单味药物应用频次、药对组合频次、用于新方聚类的核心组合及新处方。结果 治疗皮肤瘙痒内服外用方共192首符合要求,涉及264味中药,药物用药最高频次达1563次。高频药物以生地黄、赤芍、甘草、金银花、连翘为主。核心的药物组合有荆芥-茜草-黄连;荆芥-甘草-蝉蜕;荆芥-防风-黄连等;药对组合有金银花-连翘;生地黄-赤芍;连翘-甘草等;基于熵层次聚类获得新处方有17个。结论 近现代名中医治疗瘙痒以清热解毒,疏肝健脾的止痒药物为主、以活血祛湿,祛风止痒的药物为辅治疗皮肤瘙痒,研究将为中医临床治疗皮肤瘙痒用药提供方案与思路。

Objective To analyze the rule of prescriptions for pruritus by modernfamous Chinese medicine doctors base on traditional Chinese medicine inheritance auxiliary soft.Methods With “itch” and “pruritus” as the theme words, the research searched the series of 100 Traditional Chinese Medicine Clinicians in a Century,Experience Collection of Modern Famous Old Chinese Medicine and Repetition Collection of Modern Famous Old Chinese Medicine Classics.The prescriptions were collected and input into the traditional Chinese medicine inheritance assistant system(V2.5 version) to establish a prescription database, and it used software integration association rule apriori algorithm, complex system entropy clustering, unsupervised entropy hierarchical clustering and other methods to conduct data mining to obtain the application frequency of single medicine, drug pair combination frequency, core combination for new formula clustering and new prescriptions.Results A total of 192 prescriptions for pruritus were included which were applying to 14 syndromes.There were 264 traditional Chinese herbs in database.Applying frequency of herbs was 1563.The high frequency Chinese herbs were Shengdihuang(Radix Rehmannia),Chishao(Paeoniae Radix Rubra),Gancao(Glycyrrhizae Radix Et Rhizoma),Jinyinhua(Lonicerae Japonicae Flos) and Lianqiao(Forsythiae Fructus).The core combination found based on complex networks was Jingjie(Schizonepetae Herba)-Qiancao(Rubiae Radix Et Rhizoma)-Huanglian(Coptidis Rhizoma);Jingjie(Schizonepetae Herba)-Gancao(Glycyrrhizae Radix Et Rhizoma)-Chantui(Cicadae Periostracum);Jingjie(Schizonepetae Herba)-Fangfeng(Saposhnikoviae Radix)-Huanglian(Coptidis Rhizoma).The core combination found based on medicine in combination was Jinyinhua(Lonicerae Japonicae Flos)-Lianqiao(Forsythiae Fructus);Shengdihuang(Radix Rehmannia)-Chishao(Paeoniae Radix Rubra);Lianqiao(Forsythiae Fructus)-Gancao(Glycyrrhizae Radix Et Rhizoma).There were 17 new prescriptions clustering based on entropy hierarchy.Conclusion In modern times, famous traditional Chinese medicine mainly treats pruritus with antipruritic drugs that clear away heat and detoxify, sooth liver and strengthen spleen, supplemented by drugs that promote blood circulation, remove dampness and expel wind and stop itching.The research will provide a plan and idea for clinical treatment of skin pruritus with traditional Chinese medicine.