支气管舒张剂联合抗胆碱药治疗慢性阻塞性肺疾病的临床效果

Clinical Effects of Bronchodilators Combined with Anticholinergics in the Treatment of Chronic Obstructive Pulmonary Disease

目的 分析在慢性阻塞性肺疾病患者的治疗中应用支气管舒张剂联合抗胆碱药的效果。方法 抽取2021年1月至2022年12月我院收治的慢性阻塞性肺疾病患者80例作为研究样本,通过双盲法分为试验组与对照组,各40例,前者应用支气管舒张剂联合抗胆碱药物治疗,后者应用支气管舒张剂单独治疗,比较两组患者治疗前后血气分析指标(SaO_(2)、PaO_(2)、PaCO_(2))、肺功能指标(第1秒用力呼气容积、呼气峰值流速、用力肺活量)、生活质量评分(躯体功能、精神状态、角色功能)、并发症发生率(咽喉不适、发热、肠胃反应)、呼吸困难评分及舒适度评分。结果 治疗前,比较两组患者的血气分析指标、肺功能指标、呼吸困难评分、舒适度评分以及生活质量评分,组间对比差异无统计学意义(P>0.05);治疗后,试验组的PaO_(2)、肺功能指标、生活质量评分及舒适度评分均较对照组高(P<0.05);试验组的SaO_(2)、PaO_(2)、并发症发生率、呼吸困难评分均较对照组低(P<0.05)。结论 在慢性阻塞性肺疾病患者的临床治疗中实施支气管舒张剂联合抗胆碱药物治疗的效果显著,不仅能改善患者的血气分析指标与肺功能,还能提升患者的生活质量,降低药物不良反应发生风险。

Objective To analyze the effect of applying bronchodilators combined with anticholinergics in the treatment of patients with chronic obstructive pulmonary disease.Methods Eighty cases of chronic obstructive pulmonary patients admitted to our hospital from January 2021 to December 2022 were taken as the study sample,and 40 cases in each group,they were divided into experimental group and reference group by double-blind method,with the former treated with bronchodilator combined with anticholinergic drugs and the latter treated with bronchodilator alone.The blood gas analysis indexes(SaO_(2),PaO_(2),PaCO_(2)),lung function indexes(forced expiratory volume in thefirst second,peak expiratory flow rate,forced vital capacity),quality of life score(somatic function,mental state,role function),complication rate(throat discomfort,fever,gastrointestinal reactions),dyspnea score and comfort score were compared between the two groups before and after treatment.Results Before treatment,blood gas analysis indexes,lung function indexes,dyspnea scores,comfort scores and quality of life scores of the two groups were compared,and there was no significant difference between them(P>0.05).After treatment,PaO_(2),lung function index,quality of life score and comfort score of the experimental group were higher than those of the control group(P<0.05).SaO_(2),PaO_(2),complication rate and dyspnea score of the experimental group were lower than those of the control group(P<0.05).Conclusion The effect of bronchodilator combined with anticholinergic drugs in the clinical treatment of patients with chronic obstructive pulmonary disease is significant,which can not only improve patients'blood gas analysis index and lung function,but also improve patients'quality of life and reduce the risk of adverse drug reactions.