硫酸镁联合小剂量阿司匹林治疗妊娠期高血压疾病的效果及安全性分析

Efficacy and safety analysis of magnesium sulfate combined with low-dose aspirin in the treatment of hypertensive diseases pregnancy

目的探究硫酸镁联合小剂量阿司匹林治疗妊娠期高血压疾病(HDP)患者的临床效果及安全性。方法选取84例HDP患者,根据随机数字表法分为试验组与对照组,每组42例。对照组采用硫酸镁治疗,试验组联合小剂量阿司匹林治疗。比较两组治疗效果、治疗前后收缩压(SBP)、舒张压(DBP)及心率(HR)水平及不良反应发生情况。结果治疗后,试验组治疗总有效率为95.24%,高于对照组的76.19%(P<0.05)。治疗后,两组SBP、DBP及HR水平均低于治疗前,且试验组低于对照组(P<0.05)。试验组不良反应发生率低于对照组(P<0.05)。结论硫酸镁联合小剂量阿司匹林治疗HDP效果显著,可改善患者血压、心率水平,安全性较高,具有积极意义。

Objective To explore the clinical effect and safety of magnesium sulfate combined with low-dose aspirin in the treatment of hypertensive diseases pregnancy(HDP).Methods 84 HDP patients were selected and divided into experimental group and control group according to random number table method,with 42 cases in each group.The control group was treated with magnesium sulfate,and the experimental group was treated with low-dose aspirin.The therapeutic effect,systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR)before and after treatment and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of experimental group was 95.24%,which was higher than that of control group 76.19%(P<0.05).After treatment,SBP,DBP and HR levels in 2 groups were lower than before treatment,and experimental group was lower than control group(P<0.05).The incidence of adverse reactions in experimental group was lower than that in control group(P<0.05).Conclusion Magnesium sulfate combined with low-dose aspirin has a significant effect in the treatment of HDP,which can improve the blood pressure and heart rate of patients with high safety and positive significance.