孕激素治疗先兆流产的临床效果

Clinical effect of progesterone in the treatment of threatened abortion

目的探讨孕激素治疗先兆流产的临床效果。方法选取50例先兆流产患者为研究对象,根据随机数字表法分为对照组与研究组,每组25例。对照组应用地屈孕酮片治疗,研究组应用孕激素治疗。比较两组治疗效果。结果治疗后,研究组治疗总有效率、保胎率高于对照组(P<0.05)。研究组阴道流血消失时间(4.11±0.74)d,下腹痛消失时间(5.45±0.78)d,对照组阴道流血消失时间(5.29±0.76)d,下腹痛消失时间(6.17±1.28)d,比较差异有统计学意义(P<0.05)。研究组孕酮、β-人绒毛膜促性腺激素(β-HCG)水平均高于对照组(P<0.05)。研究组白细胞介素-4指标高于对照组,干扰素-γ指标低于对照组(P<0.05)。结论孕激素治疗先兆流产安全、有效,能够改善激素水平,可提高保胎率。

Objective To investigate the clinical effect of progesterone in the treatment of threatened abortion.Methods 50 patients with threatened abortion were selected as research objects and divided into control group and study group according to random number table method,with 25 cases in each group.The control group was treated with dydrogesterone tablets,while the study group was treated with progesterone.The therapeutic effect of the two groups was compared.Results After treatment,the total effective rate and fetal protection rate of the study group were higher than those of the control group(P<0.05).The disappearance time of vaginal bleeding and lower abdominal pain was(4.11±0.74)d in the study group and(5.45±0.78)d in the control group,while the disappearance time of vaginal bleeding and lower abdominal pain was(5.29±0.76)d and(6.17±1.28)d in the control group,the difference was statistically significant(P<0.05).The levels of progesterone and human chorionic gonadotropin(β-HCG)in study group were higher than those in control group(P<0.05).The interleukin-4 index of the study group was higher than that of the control group,and the interferon-γindex was lower than that of the control group(P<0.05).Conclusion Progesterone in the treatment of threatened abortion is safe,effective,can improve hormone levels,can improve the survival rate.