小檗碱在多囊卵巢综合征治疗中的研究进展

Research progress of berberine in the treatment of polycystic ovary syndrome

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄妇女最常见的生殖和内分泌疾病之一,其发病机制不清,目前尚无根治方法。PCOS临床表现为胰岛素抵抗、高胰岛素血症、肥胖、高雄激素血症、心血管风险增加等。小檗碱是一种提取于黄连的生物碱,具有抗炎、抗菌、降血脂、治疗胰岛素抵抗等多重功效。近年研究表明,小檗碱在PCOS中调节激素水平、改善慢性炎症、胰岛素抵抗、排卵障碍和子宫内膜病变等方面的作用,展现出较大的临床运用前景,本文对小檗碱在PCOS治疗中的相关研究进展进行综述。

Polycystic ovary syndrome(PCOS)is one of the most common reproductive and endocrine diseases in women of childbearing age.The pathogenesis of PCOS is unclear and there is no radical cure at present.Its clinical manifestations include insulin resistance(IR),hyperinsulinemia,obesity,hyperandrogenemia(HA),increased cardiovascular risk,etc.Berberine(BBR)is an alkaloid extracted from coptis,with anti-inflammatory,antibacterial,decreasing blood lipids,treatment of IR and other multiple effects.In recent years,amounts of medical literatures have reported the therapeutic effects of BBR in PCOS,including improving hormone levels,chronic inflammation,IR,ovulation dysfunction and endometrial lesions,which shows a great prospect of clinical application.In this paper,we reviewed the research progress of BBR in the treatment of PCOS.