摘要
肝细胞癌(HCC)是一种常见的肝脏恶性肿瘤,具有发病率高、进展快、预后差等特点。近年来发现,非编码RNA(ncRNA)在肿瘤微环境(TME)中参与肿瘤免疫的调节,进而影响HCC的生物学行为。本文简述了ncRNA对TME中免疫细胞的调控作用,并介绍了ncRNA在HCC诊断和治疗中的潜在价值,以期为HCC提供潜在的诊断和治疗策略。
Hepatocellular carcinoma(HCC)is a common malignant tumor of the liver characterized by a high incidence rate,rapid progression,and poor prognosis.In recent years,it has been found that non-coding RNA(ncRNA)participates in the regulation of tumor immunity in tumor microenvironment(TME)and in turn affects the biological behavior of HCC.This article briefly describes the regulatory effect of ncRNA on immune cells in TME and introduces the potential value of ncRNA in the diagnosis and treatment of HCC,in order to provide potential diagnostic and treatment strategies for HCC.
作者
杨超然
李思柔
刘源
侯志远
王元
杨季红
YANG Chaoran;LI Sirou;LIU Yuan;HOU Zhiyuan;WANG Yuan;YANG Jihong(Department of Hepatobiliary Surgery,Affiliated Hospital of Hebei University,Baoding,Hebei 071000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2023年第4期961-967,共7页
Journal of Clinical Hepatology
基金
河北省政府资助临床医学优秀人才培养项目(361007)。
关键词
癌
肝细胞
RNA
肿瘤微环境
免疫
细胞
Carcinoma,Hepatocellular
RNA
Tumor Microenvironment
Immunity,Cellular
